Magnesium depletion score and gout: insights from NHANES data
ObjectivesGout is associated with hyperuricemia, and serum magnesium levels are negatively correlated with uric acid levels. Magnesium intake is also associated with a reduced risk of hyperuricemia. However, the relationship between the magnesium depletion score (MDS), which represents the systemic...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1485578/full |
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| author | Xu Cao Haixia Feng Huijie Wang |
| author_facet | Xu Cao Haixia Feng Huijie Wang |
| author_sort | Xu Cao |
| collection | DOAJ |
| description | ObjectivesGout is associated with hyperuricemia, and serum magnesium levels are negatively correlated with uric acid levels. Magnesium intake is also associated with a reduced risk of hyperuricemia. However, the relationship between the magnesium depletion score (MDS), which represents the systemic magnesium status, and gout is unclear. This study was conducted to investigate the association between MDS and gout as well as explore the impact of dietary magnesium intake on this relationship.MethodsWe analyzed 18,039 adults with gout data who participated in the National Health and Nutrition Examination Survey between 2007 and 2016. Magnesium deficiency status was assessed using the MDS, a comprehensive scoring tool. Considering the possible effects of dietary magnesium intake, weighted multivariable logistic regression and subgroup analyses were used to assess the correlation between MDS and gout.ResultsThe overall prevalence of gout among adults in the United States between 2007 and 2016 was 4.7%. After adjusting for confounders, MDS and gout risk showed a significant positive correlation. Individuals with an MDS of 2 and ≥ 3 had higher odds of gout than those with an MDS of 0 (MDS = 2, odds ratio: 1.86 [1.18–2.93], p = 0.008; MDS = 3, odds ratio: 2.17 [1.37–3.43], p = 0.001; p for trend <0.001). Dietary magnesium intake did not moderate the correlation between MDS and gout risk.ConclusionA positive correlation exists between magnesium deficiency, as quantified using the MDS, and gout risk among adults in the United States. Additionally, dietary magnesium intake did not alter this association. |
| format | Article |
| id | doaj-art-cdaeeb71098d4eb8931dca09130a98fe |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-cdaeeb71098d4eb8931dca09130a98fe2024-11-21T04:38:54ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.14855781485578Magnesium depletion score and gout: insights from NHANES dataXu Cao0Haixia Feng1Huijie Wang2Department of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, ChinaDepartment of Tuberculosis, Shandong Public Health Clinical Center, Jinan, Shandong, ChinaDepartment of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, ChinaObjectivesGout is associated with hyperuricemia, and serum magnesium levels are negatively correlated with uric acid levels. Magnesium intake is also associated with a reduced risk of hyperuricemia. However, the relationship between the magnesium depletion score (MDS), which represents the systemic magnesium status, and gout is unclear. This study was conducted to investigate the association between MDS and gout as well as explore the impact of dietary magnesium intake on this relationship.MethodsWe analyzed 18,039 adults with gout data who participated in the National Health and Nutrition Examination Survey between 2007 and 2016. Magnesium deficiency status was assessed using the MDS, a comprehensive scoring tool. Considering the possible effects of dietary magnesium intake, weighted multivariable logistic regression and subgroup analyses were used to assess the correlation between MDS and gout.ResultsThe overall prevalence of gout among adults in the United States between 2007 and 2016 was 4.7%. After adjusting for confounders, MDS and gout risk showed a significant positive correlation. Individuals with an MDS of 2 and ≥ 3 had higher odds of gout than those with an MDS of 0 (MDS = 2, odds ratio: 1.86 [1.18–2.93], p = 0.008; MDS = 3, odds ratio: 2.17 [1.37–3.43], p = 0.001; p for trend <0.001). Dietary magnesium intake did not moderate the correlation between MDS and gout risk.ConclusionA positive correlation exists between magnesium deficiency, as quantified using the MDS, and gout risk among adults in the United States. Additionally, dietary magnesium intake did not alter this association.https://www.frontiersin.org/articles/10.3389/fnut.2024.1485578/fullgoutmagnesium depletion scorecross-sectional studyNational Health and Nutrition Examination Surveyassociation |
| spellingShingle | Xu Cao Haixia Feng Huijie Wang Magnesium depletion score and gout: insights from NHANES data Frontiers in Nutrition gout magnesium depletion score cross-sectional study National Health and Nutrition Examination Survey association |
| title | Magnesium depletion score and gout: insights from NHANES data |
| title_full | Magnesium depletion score and gout: insights from NHANES data |
| title_fullStr | Magnesium depletion score and gout: insights from NHANES data |
| title_full_unstemmed | Magnesium depletion score and gout: insights from NHANES data |
| title_short | Magnesium depletion score and gout: insights from NHANES data |
| title_sort | magnesium depletion score and gout insights from nhanes data |
| topic | gout magnesium depletion score cross-sectional study National Health and Nutrition Examination Survey association |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1485578/full |
| work_keys_str_mv | AT xucao magnesiumdepletionscoreandgoutinsightsfromnhanesdata AT haixiafeng magnesiumdepletionscoreandgoutinsightsfromnhanesdata AT huijiewang magnesiumdepletionscoreandgoutinsightsfromnhanesdata |