Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis

Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis

Abstract Ionizing radiation (IR) can cause severe dysfunction of hematopoietic stem cells (HSCs), leading to acute or prolonged myelosuppression. In recent years, physical exercise has been recognized as a healthy lifestyle as it can fight a variety of diseases. However, whether it provides protecti...

Full description

Saved in:

Bibliographic Details
Main Authors:	Hao Zeng, Naicheng Chen, Fang Chen, Xiaoyi Zhong, Lijing Yang, Yukai Lu, Mo Chen, Mingqiang Shen, Song Wang, Shilei Chen, Jia Cao, Xi Zhang, Jinghong Zhao, Yang Xu, Junping Wang, Mengjia Hu
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Series:	Cell Communication and Signaling
Subjects:	Hematopoietic stem cell Radiation Exercise Carnosine p53 activity Senescence
Online Access:	https://doi.org/10.1186/s12964-024-01959-2
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

PEGylation renders carnosine resistant to hydrolysis by serum carnosinase and increases renal carnosine levels
by: Shiqi Zhang, et al.
Published: (2024-07-01)

Evaluation of supplementary carnosine accumulation and distribution: an initial analysis of participants in the Nucleophilic Defense Against PM Toxicity (NEAT) clinical trial
by: Shahid P. Baba, et al.
Published: (2024-08-01)

Carnosine Synthase (<i>Ts</i>ATPGD) Alleviates Lipid Peroxidation Under Transcriptional Control by an <i>Nfe2</i>-like Gene in <i>Tridacna Squamosa</i>
by: Zhuo Yang, et al.
Published: (2024-11-01)

Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine
by: Jian Qin, et al.
Published: (2025-02-01)

Improvement of Bacteriocin Production by Natural Zeolite and Detection of Antibacterial Activity of Leuconostoc carnosum Purified Carnosin
by: Haneen A. Ibrahim, et al.
Published: (2024-12-01)

Improvement of Bacteriocin Production by Natural Zeolite and Detection of Antibacterial Activity of Leuconostoc carnosum Purified Carnosin
by: Haneen A. Ibrahim, et al.
Published: (2024-12-01)

Effects of dietary l-carnosine supplementation on the growth, intestinal microbiota, and serum metabolome of fattening lambs
by: Yaxuan Meng, et al.
Published: (2025-01-01)

Exploring Secondary Amine Carnosine Derivatives: Design, Synthesis, and Properties
by: Angelica Artasensi, et al.
Published: (2024-10-01)

Effects of Carnosine Addition in Low-Fishmeal Feed on the Growth Performance, Muscle Antioxidant Capacity and Flesh Quality of Orange-Spotted Grouper (<i>Epinephelus coioides</i>)
by: Dong Li, et al.
Published: (2024-11-01)

Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol
by: Akash Kumar, et al.
Published: (2024-12-01)

Deciphering the evolving niche interactome of human hematopoietic stem cells from ontogeny to aging
by: Cong Feng, et al.
Published: (2024-12-01)

In vitro study of the Polo‐like kinase 1 inhibitor volasertib in non‐small‐cell lung cancer reveals a role for the tumor suppressor p53
by: Jolien Van denBossche, et al.
Published: (2019-05-01)

Metabolomic profiles of preterm small-for-gestational age infants
by: Koh Okuda, et al.
Published: (2025-01-01)

T-2 toxin induces senescence in human neuroblastoma SH-SY5Y cells by regulating the HIF-1α/p53/p21 pathway
by: Yating Wang, et al.
Published: (2025-01-01)

Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats
by: Omnia A. Moselhy, et al.
Published: (2025-01-01)

Pulsed radiofrequency alleviates neuropathic pain by upregulating MG53 to inhibit microglial activation
by: Yuanxin Huang, et al.
Published: (2024-12-01)

Ginger polysaccharide UGP1 suppressed human colon cancer growth via p53, Bax/Bcl-2, caspase-3 pathways and immunomodulation
by: Yanfang Qian, et al.
Published: (2023-03-01)

Advances in hematopoietic stem cell transplantation for autoimmune diseases
by: Yuxi Xu, et al.
Published: (2024-10-01)

Identification of cardiac premature senescence markers through GEO database interaction approach
by: Tiwuk Susantiningsih, et al.
Published: (2024-08-01)

Case report: TP53 c.848G>A germline mutation as a possible screening target at initial diagnosis for acute lymphoblastic leukemia
by: Fang Hua, et al.
Published: (2024-12-01)

Predictive value of TP53 RNAscope® in situ hybridization and p53 immunohistochemistry for TP53 mutational status in canine diffuse large B-cell lymphoma
by: Greta Foiani, et al.
Published: (2024-12-01)

Hematopoietic stem cell discovery: unveiling the historical and future perspective of colony-forming units assay
by: Nur Afizah Yusoff, et al.
Published: (2025-01-01)

CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION
by: Rafael de la Camara
Published: (2016-06-01)

Deciphering hematopoietic stem cell development: key signaling pathways and mechanisms
by: Saori Morino-Koga, et al.
Published: (2024-12-01)

53th Library Week
by: Tanju Özbay
Published: (2017-03-01)

PARASITIC INFECTIONS IN HEMATOPOIETIC STEM CELL TRANSPLANTATION
by: Isidro Jarque, et al.
Published: (2016-07-01)

A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer
by: Bohao Zhang, et al.
Published: (2025-01-01)

Genome-Wide Analysis of p53 Targets Reveals SCN2A as a Novel Player in p53-Induced Cell Arrest in HPV-Positive Cells
by: Yudi Zhang, et al.
Published: (2024-10-01)

Identification and prognostic analysis of metabolic genes associated with TP53 mutation in multiple myeloma
by: Xiaoyan Tang, et al.
Published: (2024-12-01)

Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl‐p53 pathway
by: Yun Zhou, et al.
Published: (2018-08-01)

The dipeptide carnosine alleviates acute pancreatitis in an experimental model
by: Heresh Rezaei, et al.
Published: (2024-12-01)

Infectious Causes of Early Mortality After Hematopoietic Stem Cell Transplantation
by: Pelin İrkören, et al.
Published: (2024-12-01)

FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis
by: Yu Cheng, et al.
Published: (2025-02-01)

Infectious hematopoietic necrosis (review)
by: K. A. Balakhnina, et al.
Published: (2024-06-01)

From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy
by: Seyed Esmaeil Ahmadi, et al.
Published: (2024-11-01)

BTF3 affects hepatocellular carcinoma progression by transcriptionally upregulating PDCD2L and inactivating p53 signaling
by: Minyu Kong, et al.
Published: (2024-12-01)

Comparison of trained and untrained girls' blood buffering capacity response to three types of recovery during Repeated High-Intensity endurance test
by: Mahtab Tavakoli, et al.
Published: (2021-09-01)

Exploring hematopoietic stem cell awareness and engagement among healthcare professionals: A cross-sectional survey
by: Vikash Chandra Mishra, et al.
Published: (2024-12-01)

Impact of TP53 mutations on the efficacy of CAR-T cell therapy in cancer
by: Regina Mirgayazova, et al.
Published: (2024-12-01)

LETERMOVIR PRIMARY CYTOMEGALOVIRUS PROPHYLAXIS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS: COULD INFECTION AND DISEASE NO LONGER BE A SIGNIFICANT PROBLEM?
by: Fabian Herrera
Published: (2024-04-01)