Prevalence of Pathological Lesions in 161 Nephrectomies: An Experience from a Teaching Hospital in Urban Industrial Area of Maharashtra
Background: Kidneys can be involved in various pathological processes. Nephrectomy is a common procedure in urological practice. Aim: The objective of the present study is to find out the frequency of various neoplastic and non-neoplastic lesions in nephrectomy specimens and to study histomorphologi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Medical Specialities |
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| Online Access: | https://journals.lww.com/10.4103/INJMS.INJMS_127_19 |
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| author | Shirish S. Chandanwale Piyusha Naragude Madhuri Singh Akshi Raj Sunita Bamanikar Archana C. Buch Kushal Shah |
| author_facet | Shirish S. Chandanwale Piyusha Naragude Madhuri Singh Akshi Raj Sunita Bamanikar Archana C. Buch Kushal Shah |
| author_sort | Shirish S. Chandanwale |
| collection | DOAJ |
| description | Background:
Kidneys can be involved in various pathological processes. Nephrectomy is a common procedure in urological practice.
Aim:
The objective of the present study is to find out the frequency of various neoplastic and non-neoplastic lesions in nephrectomy specimens and to study histomorphological features from a teaching hospital in urban industrial area.
Materials and Methods:
The study included 161 nephrectomy specimens. Grossly, findings were noted. Detailed histological features were studied. Lesions were broadly categorized into non-neoplastic and neoplastic. Nuclear Grading System was used to grade clear-cell renal cell carcinoma (RCC) and papillary RCC. The International Society of Pediatric Oncology staging was used to stage Wilms', tumors. The staging of RCC was done by tumor, node, and metastasis classification as per the World Health Organization 2016. Other clinical details were correlated with histomorphological features.
Results:
Of 161 nephrectomy specimens, 81 (50.31%) were males and 80 (49.68%) were females. The mean age was 45.43 (±19.43 standard deviation) years. 115 (71.42%) nephrectomy specimens showed -non-neoplastic lesions and 46 (28.57%) showed neoplastic lesions. The most common non-neoplastic lesions were chronic pyelonephritis in 106 (92.17%) patients. RCC (n = 36) was the most common neoplastic lesion.
Conclusion:
In developing countries like India, chronic pyelonephritis remains the most common cause of nephrectomy. Nephrectomy due to non-neoplastic lesions is more common in younger age group as compared to neoplastic lesions. Early diagnosis and better treatment modalities for inflammatory lesions of the kidney in the developing countries will reduce the rate of nephrectomies. |
| format | Article |
| id | doaj-art-cd81b9d00d874b61b18e48e4ca5fa68b |
| institution | Kabale University |
| issn | 0976-2884 0976-2892 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Specialities |
| spelling | doaj-art-cd81b9d00d874b61b18e48e4ca5fa68b2025-08-25T08:32:52ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Specialities0976-28840976-28922020-01-01111212710.4103/INJMS.INJMS_127_19Prevalence of Pathological Lesions in 161 Nephrectomies: An Experience from a Teaching Hospital in Urban Industrial Area of MaharashtraShirish S. ChandanwalePiyusha NaragudeMadhuri SinghAkshi RajSunita BamanikarArchana C. BuchKushal ShahBackground: Kidneys can be involved in various pathological processes. Nephrectomy is a common procedure in urological practice. Aim: The objective of the present study is to find out the frequency of various neoplastic and non-neoplastic lesions in nephrectomy specimens and to study histomorphological features from a teaching hospital in urban industrial area. Materials and Methods: The study included 161 nephrectomy specimens. Grossly, findings were noted. Detailed histological features were studied. Lesions were broadly categorized into non-neoplastic and neoplastic. Nuclear Grading System was used to grade clear-cell renal cell carcinoma (RCC) and papillary RCC. The International Society of Pediatric Oncology staging was used to stage Wilms', tumors. The staging of RCC was done by tumor, node, and metastasis classification as per the World Health Organization 2016. Other clinical details were correlated with histomorphological features. Results: Of 161 nephrectomy specimens, 81 (50.31%) were males and 80 (49.68%) were females. The mean age was 45.43 (±19.43 standard deviation) years. 115 (71.42%) nephrectomy specimens showed -non-neoplastic lesions and 46 (28.57%) showed neoplastic lesions. The most common non-neoplastic lesions were chronic pyelonephritis in 106 (92.17%) patients. RCC (n = 36) was the most common neoplastic lesion. Conclusion: In developing countries like India, chronic pyelonephritis remains the most common cause of nephrectomy. Nephrectomy due to non-neoplastic lesions is more common in younger age group as compared to neoplastic lesions. Early diagnosis and better treatment modalities for inflammatory lesions of the kidney in the developing countries will reduce the rate of nephrectomies.https://journals.lww.com/10.4103/INJMS.INJMS_127_19carcinomaclear cellkidneypyelonephritis |
| spellingShingle | Shirish S. Chandanwale Piyusha Naragude Madhuri Singh Akshi Raj Sunita Bamanikar Archana C. Buch Kushal Shah Prevalence of Pathological Lesions in 161 Nephrectomies: An Experience from a Teaching Hospital in Urban Industrial Area of Maharashtra Indian Journal of Medical Specialities carcinoma clear cell kidney pyelonephritis |
| title | Prevalence of Pathological Lesions in 161 Nephrectomies: An Experience from a Teaching Hospital in Urban Industrial Area of Maharashtra |
| title_full | Prevalence of Pathological Lesions in 161 Nephrectomies: An Experience from a Teaching Hospital in Urban Industrial Area of Maharashtra |
| title_fullStr | Prevalence of Pathological Lesions in 161 Nephrectomies: An Experience from a Teaching Hospital in Urban Industrial Area of Maharashtra |
| title_full_unstemmed | Prevalence of Pathological Lesions in 161 Nephrectomies: An Experience from a Teaching Hospital in Urban Industrial Area of Maharashtra |
| title_short | Prevalence of Pathological Lesions in 161 Nephrectomies: An Experience from a Teaching Hospital in Urban Industrial Area of Maharashtra |
| title_sort | prevalence of pathological lesions in 161 nephrectomies an experience from a teaching hospital in urban industrial area of maharashtra |
| topic | carcinoma clear cell kidney pyelonephritis |
| url | https://journals.lww.com/10.4103/INJMS.INJMS_127_19 |
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