RELAPSES AFTER RADICAL SUBCUTANEOUS/SKIN-SPARING MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION IN BREAST CANCER
Objective. To evaluate 3‑year disease-free survival in patients with breast cancer who underwent radical subcutaneous/skin-sparing mastectomy with simultaneous reconstruction.Patients and methods. The article analyzes 472 patients diagnosed with breast cancer who underwent radical subcutaneous/ski...
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| Format: | Article |
| Language: | Russian |
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QUASAR, LLC
2019-04-01
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| Series: | Исследования и практика в медицине |
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| Online Access: | https://www.rpmj.ru/rpmj/article/view/355 |
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| author | A. D. Zikiryakhodzhayev E. A. Rasskazova A. Yu. Tukmakov I. M. Shirokikh |
| author_facet | A. D. Zikiryakhodzhayev E. A. Rasskazova A. Yu. Tukmakov I. M. Shirokikh |
| author_sort | A. D. Zikiryakhodzhayev |
| collection | DOAJ |
| description | Objective. To evaluate 3‑year disease-free survival in patients with breast cancer who underwent radical subcutaneous/skin-sparing mastectomy with simultaneous reconstruction.Patients and methods. The article analyzes 472 patients diagnosed with breast cancer who underwent radical subcutaneous/skin-sparing mastectomy in combined or complex treatment. In the Department of Oncology and reconstructive plastic surgery of the breast and skin radical skin mastectomy was performed in 255 (54.1%) and 217 (45.9%) patients with radical subcutaneous mastectomy. Reconstruction was carried out by autotissues, expanders, followed by replacement with endoprostheses, as well as a combination of flaps and endoprostheses. The mean age of patients was 43.8 ± 2.2 (18–73) years. In 32.3% of cases patients were in the age group up to 40 years.Results. In 9 (1,7 ± 0,6%) of patients diagnosed with a recurrence of breast cancer, herewith in 5 cases of local and in 4 cases of regional recurrence (metastases in the infraclavicular lymph nodes).Treatment of recurrences of breast cancer was as follows: in two cases polychemotherapy courses were conducted, in 6 cases operations were performed — excision of relapse in the breast (3) and subclavian lymphadenectomy (1), removal of the reconstructed gland (2), in 1 case — radiation therapy.In 13% relapses of breast cancer were diagnosed at stage III of breast cancer, the lowest percentage of relapse 0.7% at stage III. In luminal type A recurrence of breast cancer was diagnosed in 1.8%, in luminal B in 2.4%, in triple negative type — 2.5%, in luminal B Her2 positive — 2.7%. Metastases of breast cancer in our group of patients were diagnosed in 22 (4.7 ± 0.9%) patients. The highest percentage of long-term metastasis in our study revealed — 12.5% at stage III, the lowest percentage of 2.8 at stage I breast cancer. 3‑year overall survival of breast cancer patients in our group was 97.8% (n = 269).Conclusion. Radical subcutaneous/skin-sparing mastectomies with simultaneous reconstruction are radical in the oncological plan of treatment and improve the quality of life in patients with breast cancer. |
| format | Article |
| id | doaj-art-cd812d4efcd943df96f7f104fb07f818 |
| institution | Kabale University |
| issn | 2410-1893 |
| language | Russian |
| publishDate | 2019-04-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Исследования и практика в медицине |
| spelling | doaj-art-cd812d4efcd943df96f7f104fb07f8182025-02-03T07:12:14ZrusQUASAR, LLCИсследования и практика в медицине2410-18932019-04-0161334010.17709/2409-2231-2019-6-1-3244RELAPSES AFTER RADICAL SUBCUTANEOUS/SKIN-SPARING MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION IN BREAST CANCERA. D. Zikiryakhodzhayev0E. A. Rasskazova1A. Yu. Tukmakov2I. M. Shirokikh3P.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, I.M.Sechenov First Moscow State Medical University (Sechenov University), Peoples’ Friendship University of Russia (RUDN University)P.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological CentreI.M.Sechenov First Moscow State Medical University (Sechenov University)Peoples’ Friendship University of Russia (RUDN University)Objective. To evaluate 3‑year disease-free survival in patients with breast cancer who underwent radical subcutaneous/skin-sparing mastectomy with simultaneous reconstruction.Patients and methods. The article analyzes 472 patients diagnosed with breast cancer who underwent radical subcutaneous/skin-sparing mastectomy in combined or complex treatment. In the Department of Oncology and reconstructive plastic surgery of the breast and skin radical skin mastectomy was performed in 255 (54.1%) and 217 (45.9%) patients with radical subcutaneous mastectomy. Reconstruction was carried out by autotissues, expanders, followed by replacement with endoprostheses, as well as a combination of flaps and endoprostheses. The mean age of patients was 43.8 ± 2.2 (18–73) years. In 32.3% of cases patients were in the age group up to 40 years.Results. In 9 (1,7 ± 0,6%) of patients diagnosed with a recurrence of breast cancer, herewith in 5 cases of local and in 4 cases of regional recurrence (metastases in the infraclavicular lymph nodes).Treatment of recurrences of breast cancer was as follows: in two cases polychemotherapy courses were conducted, in 6 cases operations were performed — excision of relapse in the breast (3) and subclavian lymphadenectomy (1), removal of the reconstructed gland (2), in 1 case — radiation therapy.In 13% relapses of breast cancer were diagnosed at stage III of breast cancer, the lowest percentage of relapse 0.7% at stage III. In luminal type A recurrence of breast cancer was diagnosed in 1.8%, in luminal B in 2.4%, in triple negative type — 2.5%, in luminal B Her2 positive — 2.7%. Metastases of breast cancer in our group of patients were diagnosed in 22 (4.7 ± 0.9%) patients. The highest percentage of long-term metastasis in our study revealed — 12.5% at stage III, the lowest percentage of 2.8 at stage I breast cancer. 3‑year overall survival of breast cancer patients in our group was 97.8% (n = 269).Conclusion. Radical subcutaneous/skin-sparing mastectomies with simultaneous reconstruction are radical in the oncological plan of treatment and improve the quality of life in patients with breast cancer.https://www.rpmj.ru/rpmj/article/view/355breast cancersubcutaneous mastectomyskin-sparing mastectomybreast reconstructionrecurrence of breast cancersurgical treatment |
| spellingShingle | A. D. Zikiryakhodzhayev E. A. Rasskazova A. Yu. Tukmakov I. M. Shirokikh RELAPSES AFTER RADICAL SUBCUTANEOUS/SKIN-SPARING MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION IN BREAST CANCER Исследования и практика в медицине breast cancer subcutaneous mastectomy skin-sparing mastectomy breast reconstruction recurrence of breast cancer surgical treatment |
| title | RELAPSES AFTER RADICAL SUBCUTANEOUS/SKIN-SPARING MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION IN BREAST CANCER |
| title_full | RELAPSES AFTER RADICAL SUBCUTANEOUS/SKIN-SPARING MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION IN BREAST CANCER |
| title_fullStr | RELAPSES AFTER RADICAL SUBCUTANEOUS/SKIN-SPARING MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION IN BREAST CANCER |
| title_full_unstemmed | RELAPSES AFTER RADICAL SUBCUTANEOUS/SKIN-SPARING MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION IN BREAST CANCER |
| title_short | RELAPSES AFTER RADICAL SUBCUTANEOUS/SKIN-SPARING MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION IN BREAST CANCER |
| title_sort | relapses after radical subcutaneous skin sparing mastectomy with simultaneous reconstruction in breast cancer |
| topic | breast cancer subcutaneous mastectomy skin-sparing mastectomy breast reconstruction recurrence of breast cancer surgical treatment |
| url | https://www.rpmj.ru/rpmj/article/view/355 |
| work_keys_str_mv | AT adzikiryakhodzhayev relapsesafterradicalsubcutaneousskinsparingmastectomywithsimultaneousreconstructioninbreastcancer AT earasskazova relapsesafterradicalsubcutaneousskinsparingmastectomywithsimultaneousreconstructioninbreastcancer AT ayutukmakov relapsesafterradicalsubcutaneousskinsparingmastectomywithsimultaneousreconstructioninbreastcancer AT imshirokikh relapsesafterradicalsubcutaneousskinsparingmastectomywithsimultaneousreconstructioninbreastcancer |