Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

Bestrophin isoform 4 (BEST4) is a newly identified subtype of the calcium-activated chloride channel family. Analysis of colonic epithelial cell diversity by single-cell RNA-sequencing has revealed the existence of a cluster of BEST4+ mature colonocytes in humans. However, if the role of BEST4 is in...

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Bibliographic Details
Main Authors: Zijing Wang, Bihan Xia, Shaochong Qi, Xian Zhang, Xiaoshuang Zhang, Yan Li, Huimin Wang, Miao Zhang, Ziyi Zhao, David Kerr, Li Yang, Shijie Cai, Jilin Yang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
colorectal cancer
bestrophin-4
hairy/enhancer of split 4
TWIST1
epithelial-mesenchymal transition
Online Access:https://elifesciences.org/articles/88879
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