Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.
In order to elucidate the cause of acute respiratory distress syndrome of unknown etiology in a pre-pandemic patient, molecular techniques were used for detection of SARS-CoV-2. We used a SARS-CoV-2 nucleocapsid protein immunofluorescence stain to retrospectively identify an individual with diffuse...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2021/5484239 |
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| author | A. Burkett S. McElwee C. Margaroli P. Bajpai A. Elkholy U. Manne K. Wille P. Benson |
| author_facet | A. Burkett S. McElwee C. Margaroli P. Bajpai A. Elkholy U. Manne K. Wille P. Benson |
| author_sort | A. Burkett |
| collection | DOAJ |
| description | In order to elucidate the cause of acute respiratory distress syndrome of unknown etiology in a pre-pandemic patient, molecular techniques were used for detection of SARS-CoV-2. We used a SARS-CoV-2 nucleocapsid protein immunofluorescence stain to retrospectively identify an individual with diffuse alveolar damage on autopsy histology who had negative respiratory virus panel results in February, 2020, in Birmingham, Alabama. In situ hybridization for SARS-CoV-2 RNA revealed evidence of widespread multiorgan SARS-CoV-2 infection. This death antecedes the first reported death of a State of Alabama resident diagnosed with SARS-CoV-2 by 26 days. |
| format | Article |
| id | doaj-art-cd5f2af3f03d47e08dc68fa5e03c9921 |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-cd5f2af3f03d47e08dc68fa5e03c99212025-02-03T05:47:39ZengWileyCase Reports in Pulmonology2090-68462090-68542021-01-01202110.1155/2021/54842395484239Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.A. Burkett0S. McElwee1C. Margaroli2P. Bajpai3A. Elkholy4U. Manne5K. Wille6P. Benson7Department of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USAIn order to elucidate the cause of acute respiratory distress syndrome of unknown etiology in a pre-pandemic patient, molecular techniques were used for detection of SARS-CoV-2. We used a SARS-CoV-2 nucleocapsid protein immunofluorescence stain to retrospectively identify an individual with diffuse alveolar damage on autopsy histology who had negative respiratory virus panel results in February, 2020, in Birmingham, Alabama. In situ hybridization for SARS-CoV-2 RNA revealed evidence of widespread multiorgan SARS-CoV-2 infection. This death antecedes the first reported death of a State of Alabama resident diagnosed with SARS-CoV-2 by 26 days.http://dx.doi.org/10.1155/2021/5484239 |
| spellingShingle | A. Burkett S. McElwee C. Margaroli P. Bajpai A. Elkholy U. Manne K. Wille P. Benson Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology. Case Reports in Pulmonology |
| title | Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology. |
| title_full | Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology. |
| title_fullStr | Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology. |
| title_full_unstemmed | Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology. |
| title_short | Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology. |
| title_sort | positive retrospective sars cov 2 testing in a case of acute respiratory distress syndrome of unknown etiology |
| url | http://dx.doi.org/10.1155/2021/5484239 |
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