The Association between Antiphospholipid and Coagulation in Pregnant Women with Blood Clotting
Background: Antiphospholipid syndrome is a systemic hematological autoimmune disease characterized by a hypercoagulable state, which is associated with vascular thrombosis and/or obstetric morbidity characterized by miscarriage, fetal death, and/or premature birth. Objective: This research study aim...
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_926_23 |
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| author | Dabah Dakil Awad Iktefa Abdul Hameed Mohammed Saeed Maha El. Jasim |
| author_facet | Dabah Dakil Awad Iktefa Abdul Hameed Mohammed Saeed Maha El. Jasim |
| author_sort | Dabah Dakil Awad |
| collection | DOAJ |
| description | Background: Antiphospholipid syndrome is a systemic hematological autoimmune disease characterized by a hypercoagulable state, which is associated with vascular thrombosis and/or obstetric morbidity characterized by miscarriage, fetal death, and/or premature birth. Objective: This research study aimed to estimate anticardiolipin [ACL; immunoglobulin (Ig)G and IgM] and lupus anticoagulant (LA) in pregnant women who have blood clots or who have previously miscarried and fetal intrauterine mortality. Materials and Methods: This study included 90 women, 60 of whom were pregnant women who had blood clots or had previously miscarried, as well as 30 nonpregnant women as a control group, aged from 20 to 41 years, from October 2022 to April 2023. The patients were referred to the Department of Gynecology and Obstetrics at a Teaching Hospital, Salahuddin. LA, ACL IgM, and ACL IgG were detected in serum by the enzyme-linked immunosorbent assay. Results: This study found that pregnant women have higher ACL IgM and IgG levels than nonpregnant women. The mean concentration (mean ±standard error) for ACL IgM was 23.43 ± 1.4, whereas ACL IgG was 33.11 ± 1.28, which is in contrast with the control group of ACL IgM (2.99 ± 0.22) and ACL IgG (3.51 ± 0.29). The differences were statistically significant (P = 0.0001). A significant increase in LA in pregnant women was 37.77 ± 1.14, whereas the control group had a lower mean amount of LA was 334.42 ± 1.05. Statistically significant differences were observed (P ≤ 0.05). Conclusion: Elevated levels of ACL and LA are the main cause of spontaneous recurrent abortions in women. |
| format | Article |
| id | doaj-art-cd404056fabb46ac94ac90b1b94aa820 |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-cd404056fabb46ac94ac90b1b94aa8202025-01-14T11:24:47ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-10-0121Suppl 2S272S27510.4103/MJBL.MJBL_926_23The Association between Antiphospholipid and Coagulation in Pregnant Women with Blood ClottingDabah Dakil AwadIktefa Abdul Hameed Mohammed SaeedMaha El. JasimBackground: Antiphospholipid syndrome is a systemic hematological autoimmune disease characterized by a hypercoagulable state, which is associated with vascular thrombosis and/or obstetric morbidity characterized by miscarriage, fetal death, and/or premature birth. Objective: This research study aimed to estimate anticardiolipin [ACL; immunoglobulin (Ig)G and IgM] and lupus anticoagulant (LA) in pregnant women who have blood clots or who have previously miscarried and fetal intrauterine mortality. Materials and Methods: This study included 90 women, 60 of whom were pregnant women who had blood clots or had previously miscarried, as well as 30 nonpregnant women as a control group, aged from 20 to 41 years, from October 2022 to April 2023. The patients were referred to the Department of Gynecology and Obstetrics at a Teaching Hospital, Salahuddin. LA, ACL IgM, and ACL IgG were detected in serum by the enzyme-linked immunosorbent assay. Results: This study found that pregnant women have higher ACL IgM and IgG levels than nonpregnant women. The mean concentration (mean ±standard error) for ACL IgM was 23.43 ± 1.4, whereas ACL IgG was 33.11 ± 1.28, which is in contrast with the control group of ACL IgM (2.99 ± 0.22) and ACL IgG (3.51 ± 0.29). The differences were statistically significant (P = 0.0001). A significant increase in LA in pregnant women was 37.77 ± 1.14, whereas the control group had a lower mean amount of LA was 334.42 ± 1.05. Statistically significant differences were observed (P ≤ 0.05). Conclusion: Elevated levels of ACL and LA are the main cause of spontaneous recurrent abortions in women.https://doi.org/10.4103/MJBL.MJBL_926_23acl iggacl igmlapregnant womenrecurrent spontaneous abortion |
| spellingShingle | Dabah Dakil Awad Iktefa Abdul Hameed Mohammed Saeed Maha El. Jasim The Association between Antiphospholipid and Coagulation in Pregnant Women with Blood Clotting Medical Journal of Babylon acl igg acl igm la pregnant women recurrent spontaneous abortion |
| title | The Association between Antiphospholipid and Coagulation in Pregnant Women with Blood Clotting |
| title_full | The Association between Antiphospholipid and Coagulation in Pregnant Women with Blood Clotting |
| title_fullStr | The Association between Antiphospholipid and Coagulation in Pregnant Women with Blood Clotting |
| title_full_unstemmed | The Association between Antiphospholipid and Coagulation in Pregnant Women with Blood Clotting |
| title_short | The Association between Antiphospholipid and Coagulation in Pregnant Women with Blood Clotting |
| title_sort | association between antiphospholipid and coagulation in pregnant women with blood clotting |
| topic | acl igg acl igm la pregnant women recurrent spontaneous abortion |
| url | https://doi.org/10.4103/MJBL.MJBL_926_23 |
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