Spatial transcriptomics and in situ immune cell profiling of the host ectocervical landscape of HIV infected Kenyan sex working women

Spatial transcriptomics and in situ immune cell profiling of the host ectocervical landscape of HIV infected Kenyan sex working women

IntroductionChronic immune activation is a hallmark of human immunodeficiency virus (HIV) infection that significantly impacts disease pathogenesis. However, in-depth studies characterizing the immunological landscape of the ectocervix during chronic HIV infection remain scarce despite the importanc...

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Bibliographic Details
Main Authors: Mathias Franzén Boger, Vilde Kaldhusdal, Anna Pascual-Reguant, Sandy Kroh, Ralf Uecker, Adam D. Burgener, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Keith R. Fowke, Anja E. Hauser, Annelie Tjernlund, Kristina Broliden
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
HIV
spatial transcriptomics
multi-epitope ligand cartography
mucosal immunology
T cells
B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1483346/full
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