Ultra-high gradient performance 3-Tesla MRI for super-fast and high-quality prostate imaging: initial experience
Abstract Objectives To implement and evaluate a super-fast and high-quality biparametric MRI (bpMRI) protocol for prostate imaging acquired at a new ultra-high gradient 3.0-T MRI system. Methods Participants with clinically suspected prostate cancer prospectively underwent a multiparametric MRI (mpM...
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| Language: | English |
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SpringerOpen
2024-11-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-024-01862-x |
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| author | Leon M. Bischoff Christoph Endler Philipp Krausewitz Joerg Ellinger Niklas Klümper Alexander Isaak Narine Mesropyan Dmitrij Kravchenko Sebastian Nowak Daniel Kuetting Alois M. Sprinkart Petra Mürtz Claus C. Pieper Ulrike Attenberger Julian A. Luetkens |
| author_facet | Leon M. Bischoff Christoph Endler Philipp Krausewitz Joerg Ellinger Niklas Klümper Alexander Isaak Narine Mesropyan Dmitrij Kravchenko Sebastian Nowak Daniel Kuetting Alois M. Sprinkart Petra Mürtz Claus C. Pieper Ulrike Attenberger Julian A. Luetkens |
| author_sort | Leon M. Bischoff |
| collection | DOAJ |
| description | Abstract Objectives To implement and evaluate a super-fast and high-quality biparametric MRI (bpMRI) protocol for prostate imaging acquired at a new ultra-high gradient 3.0-T MRI system. Methods Participants with clinically suspected prostate cancer prospectively underwent a multiparametric MRI (mpMRI) on a new 3.0-T MRI scanner (maximum gradient strength: 200 mT/m, maximum slew rate: 200 T/m/s). The bpMRI protocol was extracted from the full mpMRI protocol, including axial T2-weighted and diffusion-weighted (DWI) sequences (b0/800, b1500). Overall image quality was rated by two readers on a five-point Likert scale from (1) non-diagnostic to (5) excellent. PI-RADS 2.1 scores were assessed by three readers separately for the bpMRI and mpMRI protocols. Cohen’s and Fleiss’ κ were calculated for PI-RADS agreement between protocols and interrater reliability between readers, respectively. Results Seventy-seven male participants (mean age, 66 ± 8 years) were included. Acquisition time of the bpMRI protocol was reduced by 62% (bpMRI: 5 min, 33 ± 21 s; mpMRI: 14 min, 50 ± 42 s). The bpMRI protocol showed excellent overall image quality for both the T2-weighted (median score both readers: 5 [IQR: 4–5]) and DWI (b1500) sequence (median score reader 1: 4 [IQR: 4–5]; reader 2: 4 [IQR: 4–4]). PI-RADS score agreement between protocols was excellent (Cohen’s κ range: 0.91–0.95 [95% CI: 0.89, 0.99]) with an overall good interrater reliability (Fleiss’ κ, 0.86 [95% CI: 0.80, 0.92]). Conclusion Ultra-high gradient MRI allows the establishment of a high-quality and rapidly acquired bpMRI with high PI-RADS agreement to a full mpMRI protocol. Trials registration Clinicaltrials.gov, NCT06244680, Registered 06 February 2024, retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT06244680 . Critical relevance statement A novel 3.0-Tesla MRI system with an ultra-high gradient performance enabled high-quality biparametric prostate MRI in 5.5 min while achieving excellent PI-RADS agreement with a standard multiparametric protocol. Key Points Multi- and biparametric prostate MRIs were prospectively acquired utilizing a maximum gradient of 200 mT/m. Super-fast biparametric MRIs showed excellent image quality and had high PI-RADS agreement with multiparametric MRIs. Implementation of high gradient MRI in clinical routine allows accelerated and high-quality biparametric prostate examinations. Graphical Abstract |
| format | Article |
| id | doaj-art-ccd66e77264b4eb1a8628b55dbff0dd1 |
| institution | Kabale University |
| issn | 1869-4101 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj-art-ccd66e77264b4eb1a8628b55dbff0dd12024-12-01T12:29:25ZengSpringerOpenInsights into Imaging1869-41012024-11-0115111010.1186/s13244-024-01862-xUltra-high gradient performance 3-Tesla MRI for super-fast and high-quality prostate imaging: initial experienceLeon M. Bischoff0Christoph Endler1Philipp Krausewitz2Joerg Ellinger3Niklas Klümper4Alexander Isaak5Narine Mesropyan6Dmitrij Kravchenko7Sebastian Nowak8Daniel Kuetting9Alois M. Sprinkart10Petra Mürtz11Claus C. Pieper12Ulrike Attenberger13Julian A. Luetkens14Department of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Urology, University Hospital BonnDepartment of Urology, University Hospital BonnDepartment of Urology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnDepartment of Diagnostic and Interventional Radiology, University Hospital BonnAbstract Objectives To implement and evaluate a super-fast and high-quality biparametric MRI (bpMRI) protocol for prostate imaging acquired at a new ultra-high gradient 3.0-T MRI system. Methods Participants with clinically suspected prostate cancer prospectively underwent a multiparametric MRI (mpMRI) on a new 3.0-T MRI scanner (maximum gradient strength: 200 mT/m, maximum slew rate: 200 T/m/s). The bpMRI protocol was extracted from the full mpMRI protocol, including axial T2-weighted and diffusion-weighted (DWI) sequences (b0/800, b1500). Overall image quality was rated by two readers on a five-point Likert scale from (1) non-diagnostic to (5) excellent. PI-RADS 2.1 scores were assessed by three readers separately for the bpMRI and mpMRI protocols. Cohen’s and Fleiss’ κ were calculated for PI-RADS agreement between protocols and interrater reliability between readers, respectively. Results Seventy-seven male participants (mean age, 66 ± 8 years) were included. Acquisition time of the bpMRI protocol was reduced by 62% (bpMRI: 5 min, 33 ± 21 s; mpMRI: 14 min, 50 ± 42 s). The bpMRI protocol showed excellent overall image quality for both the T2-weighted (median score both readers: 5 [IQR: 4–5]) and DWI (b1500) sequence (median score reader 1: 4 [IQR: 4–5]; reader 2: 4 [IQR: 4–4]). PI-RADS score agreement between protocols was excellent (Cohen’s κ range: 0.91–0.95 [95% CI: 0.89, 0.99]) with an overall good interrater reliability (Fleiss’ κ, 0.86 [95% CI: 0.80, 0.92]). Conclusion Ultra-high gradient MRI allows the establishment of a high-quality and rapidly acquired bpMRI with high PI-RADS agreement to a full mpMRI protocol. Trials registration Clinicaltrials.gov, NCT06244680, Registered 06 February 2024, retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT06244680 . Critical relevance statement A novel 3.0-Tesla MRI system with an ultra-high gradient performance enabled high-quality biparametric prostate MRI in 5.5 min while achieving excellent PI-RADS agreement with a standard multiparametric protocol. Key Points Multi- and biparametric prostate MRIs were prospectively acquired utilizing a maximum gradient of 200 mT/m. Super-fast biparametric MRIs showed excellent image quality and had high PI-RADS agreement with multiparametric MRIs. Implementation of high gradient MRI in clinical routine allows accelerated and high-quality biparametric prostate examinations. Graphical Abstracthttps://doi.org/10.1186/s13244-024-01862-xMultiparametric MRIBiparametric MRIProstate cancerPI-RADSUltra-high gradient strength |
| spellingShingle | Leon M. Bischoff Christoph Endler Philipp Krausewitz Joerg Ellinger Niklas Klümper Alexander Isaak Narine Mesropyan Dmitrij Kravchenko Sebastian Nowak Daniel Kuetting Alois M. Sprinkart Petra Mürtz Claus C. Pieper Ulrike Attenberger Julian A. Luetkens Ultra-high gradient performance 3-Tesla MRI for super-fast and high-quality prostate imaging: initial experience Insights into Imaging Multiparametric MRI Biparametric MRI Prostate cancer PI-RADS Ultra-high gradient strength |
| title | Ultra-high gradient performance 3-Tesla MRI for super-fast and high-quality prostate imaging: initial experience |
| title_full | Ultra-high gradient performance 3-Tesla MRI for super-fast and high-quality prostate imaging: initial experience |
| title_fullStr | Ultra-high gradient performance 3-Tesla MRI for super-fast and high-quality prostate imaging: initial experience |
| title_full_unstemmed | Ultra-high gradient performance 3-Tesla MRI for super-fast and high-quality prostate imaging: initial experience |
| title_short | Ultra-high gradient performance 3-Tesla MRI for super-fast and high-quality prostate imaging: initial experience |
| title_sort | ultra high gradient performance 3 tesla mri for super fast and high quality prostate imaging initial experience |
| topic | Multiparametric MRI Biparametric MRI Prostate cancer PI-RADS Ultra-high gradient strength |
| url | https://doi.org/10.1186/s13244-024-01862-x |
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