Serum Levels of SDF-1 and CXCR4 in Breast Cancer: Correlation with Disease Progression and Chemotherapy Response in Iraqi Women
Breast cancer is the most frequently diagnosed cancer among women worldwide and remains a significant global health issue. Autophagy plays a dual role in breast cancer, influencing both anti-tumor immunity and tumor progression. This study aimed to investigate the role of autophagy markers, specific...
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University of Kirkuk
2024-12-01
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| Series: | Kirkuk Journal of Science |
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| Online Access: | https://kujss.uokirkuk.edu.iq/article_185826_d52817d15786413efe99369681c4c7b1.pdf |
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| author | Noor Al Rubaiey Hazima ALabassi |
| author_facet | Noor Al Rubaiey Hazima ALabassi |
| author_sort | Noor Al Rubaiey |
| collection | DOAJ |
| description | Breast cancer is the most frequently diagnosed cancer among women worldwide and remains a significant global health issue. Autophagy plays a dual role in breast cancer, influencing both anti-tumor immunity and tumor progression. This study aimed to investigate the role of autophagy markers, specifically SDF1 and CXCR4, in breast cancer pathogenesis among Iraqi women.A total of 90 participants, aged 25–65 years, were divided into three groups: 30 newly diagnosed breast cancer patients, 30 patients undergoing chemotherapy, and 30 healthy controls. The chemotherapy regimen for the treated group included Adriamycin (60 mg/m²) combined with cyclophosphamide, administered in 21-day cycles. Diagnosis was confirmed through mammography and histopathological examination. Blood samples (3 ml) were collected, processed, and stored for analysis, with serum levels of SDF1 and CXCR4 measured using ELISA kits.The study revealed that SDF1 levels were significantly elevated in newly diagnosed patients (84.91 ± 4.2 pg/ml) compared to chemotherapy patients (59.94 ± 2.18 pg/ml) and controls (57.00 ± 3.47 pg/ml), with p≤0.001. Similarly, CXCR4 levels were highest in newly diagnosed patients (0.5 ± 0.06 ng/ml), followed by controls (0.11 ± 0.01 ng/ml) and chemotherapy patients (0.08 ± 0.01 ng/ml), also with p≤0.001. A moderate positive correlation between SDF1 and CXCR4 (r = 0.5, p = 0.001) was observed, indicating their potential role in breast cancer progression.These findings highlight the significance of SDF1 and CXCR4 as potential markers for understanding breast cancer pathogenesis and progression, offering insights for targeted therapeutic |
| format | Article |
| id | doaj-art-ccb9e88a2f6d41feb570017ae2f3c9b7 |
| institution | Kabale University |
| issn | 3005-4788 3005-4796 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University of Kirkuk |
| record_format | Article |
| series | Kirkuk Journal of Science |
| spelling | doaj-art-ccb9e88a2f6d41feb570017ae2f3c9b72025-01-10T16:36:34ZengUniversity of KirkukKirkuk Journal of Science3005-47883005-47962024-12-01194374910.32894/kujss.2024.153313.1180185826Serum Levels of SDF-1 and CXCR4 in Breast Cancer: Correlation with Disease Progression and Chemotherapy Response in Iraqi WomenNoor Al Rubaiey0Hazima ALabassi1Department of Biology, College of Education for Pure Science (Ibn Al- Haitham), University of Baghdad, Baghdad, Iraq.Department of Biology, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Iraq , Baghdad .Breast cancer is the most frequently diagnosed cancer among women worldwide and remains a significant global health issue. Autophagy plays a dual role in breast cancer, influencing both anti-tumor immunity and tumor progression. This study aimed to investigate the role of autophagy markers, specifically SDF1 and CXCR4, in breast cancer pathogenesis among Iraqi women.A total of 90 participants, aged 25–65 years, were divided into three groups: 30 newly diagnosed breast cancer patients, 30 patients undergoing chemotherapy, and 30 healthy controls. The chemotherapy regimen for the treated group included Adriamycin (60 mg/m²) combined with cyclophosphamide, administered in 21-day cycles. Diagnosis was confirmed through mammography and histopathological examination. Blood samples (3 ml) were collected, processed, and stored for analysis, with serum levels of SDF1 and CXCR4 measured using ELISA kits.The study revealed that SDF1 levels were significantly elevated in newly diagnosed patients (84.91 ± 4.2 pg/ml) compared to chemotherapy patients (59.94 ± 2.18 pg/ml) and controls (57.00 ± 3.47 pg/ml), with p≤0.001. Similarly, CXCR4 levels were highest in newly diagnosed patients (0.5 ± 0.06 ng/ml), followed by controls (0.11 ± 0.01 ng/ml) and chemotherapy patients (0.08 ± 0.01 ng/ml), also with p≤0.001. A moderate positive correlation between SDF1 and CXCR4 (r = 0.5, p = 0.001) was observed, indicating their potential role in breast cancer progression.These findings highlight the significance of SDF1 and CXCR4 as potential markers for understanding breast cancer pathogenesis and progression, offering insights for targeted therapeutic https://kujss.uokirkuk.edu.iq/article_185826_d52817d15786413efe99369681c4c7b1.pdftumorimmune responsesmetastasischemotherapy |
| spellingShingle | Noor Al Rubaiey Hazima ALabassi Serum Levels of SDF-1 and CXCR4 in Breast Cancer: Correlation with Disease Progression and Chemotherapy Response in Iraqi Women Kirkuk Journal of Science tumor immune responses metastasis chemotherapy |
| title | Serum Levels of SDF-1 and CXCR4 in Breast Cancer: Correlation with Disease Progression and Chemotherapy Response in Iraqi Women |
| title_full | Serum Levels of SDF-1 and CXCR4 in Breast Cancer: Correlation with Disease Progression and Chemotherapy Response in Iraqi Women |
| title_fullStr | Serum Levels of SDF-1 and CXCR4 in Breast Cancer: Correlation with Disease Progression and Chemotherapy Response in Iraqi Women |
| title_full_unstemmed | Serum Levels of SDF-1 and CXCR4 in Breast Cancer: Correlation with Disease Progression and Chemotherapy Response in Iraqi Women |
| title_short | Serum Levels of SDF-1 and CXCR4 in Breast Cancer: Correlation with Disease Progression and Chemotherapy Response in Iraqi Women |
| title_sort | serum levels of sdf 1 and cxcr4 in breast cancer correlation with disease progression and chemotherapy response in iraqi women |
| topic | tumor immune responses metastasis chemotherapy |
| url | https://kujss.uokirkuk.edu.iq/article_185826_d52817d15786413efe99369681c4c7b1.pdf |
| work_keys_str_mv | AT nooralrubaiey serumlevelsofsdf1andcxcr4inbreastcancercorrelationwithdiseaseprogressionandchemotherapyresponseiniraqiwomen AT hazimaalabassi serumlevelsofsdf1andcxcr4inbreastcancercorrelationwithdiseaseprogressionandchemotherapyresponseiniraqiwomen |