Transcriptomic analysis reveals a critical role for activating Gsα mutations in spontaneous feline hyperthyroidism

Transcriptomic analysis reveals a critical role for activating Gsα mutations in spontaneous feline hyperthyroidism

Abstract Feline hyperthyroidism (FHT) is a debilitating disease affecting > 10% of elderly cats. It is generally characterised by chronic elevation of thyroid hormone in the absence of circulating TSH. Understanding of the molecular pathogenesis of FHT is currently limited. However, FHT shares cl...

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Main Authors: Thomas K. Hiron, Joana Aguiar, Jonathan M. Williams, Sara Falcone, Paul A. Norman, Jonathan Elliott, Robert C. Fowkes, Harriet M. Syme, Lucy J. Davison
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-79564-z
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https://doi.org/10.1038/s41598-024-79564-z

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