JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease
Objective: Behçet’s disease (BD) is a chronic, multisystemic inflammatory disorder with an unknown etiology. T cells are crucial in the pathogenesis of BD. Janus kinase-2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) are intracellular signal transduction molecules that increa...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-01-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/lessigreaterjak2lessigreater-lessigreaterstat3lessigreater-gene-polymorphisms-in-turkish-patients-with-behcets-disease/doi/gmj.galenos.2023.3924 |
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| author | Darya Farhoomand Aksoy Rahime Aksoy Sevim Gönen Ümit Ölmez |
| author_facet | Darya Farhoomand Aksoy Rahime Aksoy Sevim Gönen Ümit Ölmez |
| author_sort | Darya Farhoomand Aksoy |
| collection | DOAJ |
| description | Objective: Behçet’s disease (BD) is a chronic, multisystemic inflammatory disorder with an unknown etiology. T cells are crucial in the pathogenesis of BD. Janus kinase-2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) are intracellular signal transduction molecules that increase the risk of developing some autoimmune diseases. By modifying Th1 and Th17 responses, the JAK2 and STAT3 signaling pathways are believed to be effective in BD. This study aimed to determine whether BD in the Turkish population is related to JAK2 and STAT3 polymorphisms.
Methods: A case-control study included a total of 197 patients with BD who were referred to the Ankara University Faculty of Medicine and 100 healthy individuals without a history of autoimmune disease or BD in their family or themselves. The genotypes of one single-nucleotide polymorphism (SNPs) (rs10974944) in JAK2 and one SNPs (rs2293152) in the STAT3 gene were analyzed using polymerase chain reaction restriction fragment length polymorphism.
Results: The result of this investigation identified that in this disease, there was a significantly increased frequency of the CG genotype of the rs10974944 JAK2 in patients with BD compared with a control group (p=0.031, odds ratio [95% confidence interval: 0.392 (0.163- 0.942)]. None of the tested SNPs (rs2293152) of STAT3 were associated with BD.
Conclusion: This is the first investigation into JAK2 and STAT3 polymorphisms in Turkish patients with BD. These results suggest that a JAK2 genetic polymorphism may be associated with BD susceptibility. |
| format | Article |
| id | doaj-art-ccb624fb733844be8a1e7a7c9a256a5f |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-ccb624fb733844be8a1e7a7c9a256a5f2025-01-17T11:49:48ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-01-01351646810.12996/gmj.galenos.2023.3924JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s DiseaseDarya Farhoomand Aksoy0https://orcid.org/0000-0002-7731-648XRahime Aksoy1https://orcid.org/0000-0001-8433-3627Sevim Gönen2https://orcid.org/0000-0002-2059-6193Ümit Ölmez3https://orcid.org/0000-0003-0915-0446Ankara Unversity Faculty of Medicine, Department of Immunology and Allergy, Ankara, Türkiye ̇Ankara Unversity Faculty of Medicine, Department of Hematology, Ankara, TürkiyeGazi University Faculty of Medicine, Department of Pediatric Nephrology Ankara, TürkiyeAnkara Unversity Faculty of Medicine, Department of Immunology and Allergy, Ankara, Türkiye ̇Objective: Behçet’s disease (BD) is a chronic, multisystemic inflammatory disorder with an unknown etiology. T cells are crucial in the pathogenesis of BD. Janus kinase-2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) are intracellular signal transduction molecules that increase the risk of developing some autoimmune diseases. By modifying Th1 and Th17 responses, the JAK2 and STAT3 signaling pathways are believed to be effective in BD. This study aimed to determine whether BD in the Turkish population is related to JAK2 and STAT3 polymorphisms. Methods: A case-control study included a total of 197 patients with BD who were referred to the Ankara University Faculty of Medicine and 100 healthy individuals without a history of autoimmune disease or BD in their family or themselves. The genotypes of one single-nucleotide polymorphism (SNPs) (rs10974944) in JAK2 and one SNPs (rs2293152) in the STAT3 gene were analyzed using polymerase chain reaction restriction fragment length polymorphism. Results: The result of this investigation identified that in this disease, there was a significantly increased frequency of the CG genotype of the rs10974944 JAK2 in patients with BD compared with a control group (p=0.031, odds ratio [95% confidence interval: 0.392 (0.163- 0.942)]. None of the tested SNPs (rs2293152) of STAT3 were associated with BD. Conclusion: This is the first investigation into JAK2 and STAT3 polymorphisms in Turkish patients with BD. These results suggest that a JAK2 genetic polymorphism may be associated with BD susceptibility.https://gazimedj.com/articles/lessigreaterjak2lessigreater-lessigreaterstat3lessigreater-gene-polymorphisms-in-turkish-patients-with-behcets-disease/doi/gmj.galenos.2023.3924behçet diseasestat3jak2polymorphism |
| spellingShingle | Darya Farhoomand Aksoy Rahime Aksoy Sevim Gönen Ümit Ölmez JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease Gazi Medical Journal behçet disease stat3 jak2 polymorphism |
| title | JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease |
| title_full | JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease |
| title_fullStr | JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease |
| title_full_unstemmed | JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease |
| title_short | JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease |
| title_sort | jak2 stat3 gene polymorphisms in turkish patients with behcet s disease |
| topic | behçet disease stat3 jak2 polymorphism |
| url | https://gazimedj.com/articles/lessigreaterjak2lessigreater-lessigreaterstat3lessigreater-gene-polymorphisms-in-turkish-patients-with-behcets-disease/doi/gmj.galenos.2023.3924 |
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