Evaluation of daily glycemic profiles in well controlled children with type 1 diabetes mellitus using a continuous glucose monitoring system
Introduction: Effective diabetes mellitus management requires to maintain blood glucose levels in a narrow range between hyperglycemia causing late complications, and danger of severe hypoglycemia. This objective may be difficult to achieve especially in small children. The aim of the study: Evaluat...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2009-03-01
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| Series: | Pediatric Endocrinology, Diabetes and Metabolism |
| Subjects: | |
| Online Access: | http://cornetis.pl/pliki/ED/2009/1/ED_2009_1_29.pdf |
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| Summary: | Introduction: Effective diabetes mellitus management requires to maintain blood glucose levels in a narrow range between hyperglycemia causing late complications, and danger of severe hypoglycemia. This objective may be difficult to achieve especially in small children. The aim of the study: Evaluation of daily glycemic profiles obtained using a continuous glucose monitoring system in well controlled children with type 1 diabetes mellitus. Material and methods: In 32 children (19 boys), aged 8.34±3.38 years, with a good metabolic control (HbA1c=6.59±0.66%), T1DM duration of 3.76±2.2 years, and daily insulin requirement of 0.69±0.2 U/kg, the Medtronic Guardian RT™ device was applied for 2.92±0.61 days. The data analysis performed in periods ofday (7:00-22:00), night (22:00-7:00) and full recording consisted of following parameters: mean (mG) and standard deviation of glucose (sdG), excursion duration times (t) and mean glucose in following excursions (mGex): hyperglycemias >160 and >135 mg/dL (8.9 and 7.5 mmol/ L), and hypoglycemias <55 and <70 mg/dL (3 and 3.9 mmol/L). Results: The analyzed parameters did not vary between periods ofday, night and full recording. For full recording values were: mG=120.9 mg/dL (6.72 mmol/L), sdG=39.73 mg/dL (2.18 mmol/L), t>135=32.04%, t>160=17.29%, mGex>135=169,78 mg/dL (9.43 mmol/L), mGex>160=189.2 mg/dL (10.51 mmol/L), t<55=0.91%, t<70=8.78%, Gex<55=51.99 mg/dL (2.89 mmol/L), mGex<70=63.18 mg/dL (3.51 mmol/L). The correlation coefficient values between HbA1c level and calculated parameters were the highest for full recording: mG r=0.44 (p<0.02), t>135 r=0.49 (p=0.005), t>160 r=0.45 (p=0.01), mGex>135 r=0.49 (p=0.005), mGex>160 r=0.47 (p<0.01). No significant correlations between the number of calibrations per day (6.62±2.53), and mG, t>135 and t>160 were found. Conclusions: Continuous glucose monitoring showed almost-physiological glycemic profiles in well controlled children. Glycemic excursions times were very short. |
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| ISSN: | 2081-237X |