A HEALTH RELATED QUALITY OF LIFE AND PSYCHOPATHOLOGICAL SYMPTOMS IN PEOPLE WITH HEMOPHILIA, BLOODBORNE CO-INFECTIONS AND COMORBIDITIES: AN ITALIAN MULTICENTER OBSERVATIONAL STUDY
Background: The health-related quality of life (HRQoL) of people with hemophilia (PWH) is an important issue, especially considering people suffering from chronic diseases beyond hemophilia. The principal aim of this study was to investigate the presence and relevance of psychological symptoms, bot...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2023-01-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/5153 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841563394363097088 |
|---|---|
| author | Mario Schiavoni CARLO PRUNETI SARA GUIDOTTI ALESSANDRA MOSCATELLO FRANCESCA GIORDANO ANTONELLA COLUCCIA RITA CARLOTTA SANTORO MARIA FRANCESCA MANSUETO EZIO ZANON RENATO MARINO ISABELLA CANTORI RAIMONDO DE CRISTOFARO |
| author_facet | Mario Schiavoni CARLO PRUNETI SARA GUIDOTTI ALESSANDRA MOSCATELLO FRANCESCA GIORDANO ANTONELLA COLUCCIA RITA CARLOTTA SANTORO MARIA FRANCESCA MANSUETO EZIO ZANON RENATO MARINO ISABELLA CANTORI RAIMONDO DE CRISTOFARO |
| author_sort | Mario Schiavoni |
| collection | DOAJ |
| description |
Background: The health-related quality of life (HRQoL) of people with hemophilia (PWH) is an important issue, especially considering people suffering from chronic diseases beyond hemophilia. The principal aim of this study was to investigate the presence and relevance of psychological symptoms, both internalizing and externalizing, lifestyle, and HRQoL in a group of Italian PWH with chronic bloodborne co-infections and comorbidities. Furthermore, the research describes the association between psychological aspects and the impact of disease-related characteristics (type of hemophilia, presence of co-infections, and comorbidities) on them.
Methods: Seventy patients (mean age 46.77±11.3), 64 with severe hemophilia A (Factor VIII: C < 1 IU/dL) and 6 with severe hemophilia B (Factor IX <1 IU/dL), were consecutively recruited from seven Hemophilia Centers in Italy of Italian Association of Hemophilia Centers (AICE). In order to assess psychological symptoms, HRQoL, and lifestyle, three psychological questionnaires were administered (the SCL-90-R, SF-36, and PSQ, respectively).
Results: A general decline in the quality of life and an increase in the tendency to adopt a lifestyle characterized by hyperactivity emerged. Inverse correlations were found between HRQoL and psychological distress. Although the SCL-90-R did not reveal symptoms above the clinical cut-off, co-infections significantly increased anxiety, depression, somatizations, paranoia, and social withdrawal. Lastly, HRQoL is impaired by co-infections as well as comorbidities.
Conclusion: Our preliminary results must be confirmed to deepen the findings between mental health and hemophilia.
|
| format | Article |
| id | doaj-art-cca33725b0ef44bba1ab655be716aa53 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-cca33725b0ef44bba1ab655be716aa532025-01-03T00:00:35ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062023-01-0115110.4084/MJHID.2023.005A HEALTH RELATED QUALITY OF LIFE AND PSYCHOPATHOLOGICAL SYMPTOMS IN PEOPLE WITH HEMOPHILIA, BLOODBORNE CO-INFECTIONS AND COMORBIDITIES: AN ITALIAN MULTICENTER OBSERVATIONAL STUDYMario Schiavoni0CARLO PRUNETI1SARA GUIDOTTI2ALESSANDRA MOSCATELLO3FRANCESCA GIORDANO4ANTONELLA COLUCCIA5RITA CARLOTTA SANTORO6MARIA FRANCESCA MANSUETO7EZIO ZANON8RENATO MARINO9ISABELLA CANTORI10RAIMONDO DE CRISTOFARO11Hemophilia and Rare Coagulopathies Center -Dept. of Internal Medicine, “ I. Veris Delli Ponti“ Hospital-Scorrano-ASL Lecce, ItalyClinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology Labs., Dept. of Medicine and Surgery, University of Parma, ItalyClinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology Labs., Dept. of Medicine and Surgery, University of Parma, ItalyPenitentiary Medicine- Socio-sanitary District ASL-Lecce, Italy. Service of Pathological Addictions-Gallipoli-ASL Lecce, ItalyHemophilia and Rare Coagulopathies Center -Dept. of Internal Medicine, “ I. Veris Delli Ponti“ Hospital-Scorrano-ASL Lecce, Italy. Hemostasis and Thrombosis Unit, Pugliese-Ciaccio Hospital, Catanzaro, ItalyRegional Reference Center for Coagulopathies in Children and Adults, Hematology Unit, Oncol-ogy Dept.- Policlinico University, Palermo, ItalyMultidisciplinary HUB Regional Center for Prevention, Prophylaxis and Advanced Treatment of Hemophilic Arthropathy,General Medicine University Hospital of Padua, ItalyHemophilia and Thrombosis Center, Policlinico-University, Bari, Italy. Haemophilia Center, Department of Transfusion Medicine, Hospital of Macerata, Macerata, Italy.Hemorrhagic and Thrombotic Diseases Center, Foundation "A. Gemelli" IRCCS University Ho-spital, Rome, Italy. Background: The health-related quality of life (HRQoL) of people with hemophilia (PWH) is an important issue, especially considering people suffering from chronic diseases beyond hemophilia. The principal aim of this study was to investigate the presence and relevance of psychological symptoms, both internalizing and externalizing, lifestyle, and HRQoL in a group of Italian PWH with chronic bloodborne co-infections and comorbidities. Furthermore, the research describes the association between psychological aspects and the impact of disease-related characteristics (type of hemophilia, presence of co-infections, and comorbidities) on them. Methods: Seventy patients (mean age 46.77±11.3), 64 with severe hemophilia A (Factor VIII: C < 1 IU/dL) and 6 with severe hemophilia B (Factor IX <1 IU/dL), were consecutively recruited from seven Hemophilia Centers in Italy of Italian Association of Hemophilia Centers (AICE). In order to assess psychological symptoms, HRQoL, and lifestyle, three psychological questionnaires were administered (the SCL-90-R, SF-36, and PSQ, respectively). Results: A general decline in the quality of life and an increase in the tendency to adopt a lifestyle characterized by hyperactivity emerged. Inverse correlations were found between HRQoL and psychological distress. Although the SCL-90-R did not reveal symptoms above the clinical cut-off, co-infections significantly increased anxiety, depression, somatizations, paranoia, and social withdrawal. Lastly, HRQoL is impaired by co-infections as well as comorbidities. Conclusion: Our preliminary results must be confirmed to deepen the findings between mental health and hemophilia. http://www.mjhid.org/index.php/mjhid/article/view/5153 |
| spellingShingle | Mario Schiavoni CARLO PRUNETI SARA GUIDOTTI ALESSANDRA MOSCATELLO FRANCESCA GIORDANO ANTONELLA COLUCCIA RITA CARLOTTA SANTORO MARIA FRANCESCA MANSUETO EZIO ZANON RENATO MARINO ISABELLA CANTORI RAIMONDO DE CRISTOFARO A HEALTH RELATED QUALITY OF LIFE AND PSYCHOPATHOLOGICAL SYMPTOMS IN PEOPLE WITH HEMOPHILIA, BLOODBORNE CO-INFECTIONS AND COMORBIDITIES: AN ITALIAN MULTICENTER OBSERVATIONAL STUDY Mediterranean Journal of Hematology and Infectious Diseases |
| title | A HEALTH RELATED QUALITY OF LIFE AND PSYCHOPATHOLOGICAL SYMPTOMS IN PEOPLE WITH HEMOPHILIA, BLOODBORNE CO-INFECTIONS AND COMORBIDITIES: AN ITALIAN MULTICENTER OBSERVATIONAL STUDY |
| title_full | A HEALTH RELATED QUALITY OF LIFE AND PSYCHOPATHOLOGICAL SYMPTOMS IN PEOPLE WITH HEMOPHILIA, BLOODBORNE CO-INFECTIONS AND COMORBIDITIES: AN ITALIAN MULTICENTER OBSERVATIONAL STUDY |
| title_fullStr | A HEALTH RELATED QUALITY OF LIFE AND PSYCHOPATHOLOGICAL SYMPTOMS IN PEOPLE WITH HEMOPHILIA, BLOODBORNE CO-INFECTIONS AND COMORBIDITIES: AN ITALIAN MULTICENTER OBSERVATIONAL STUDY |
| title_full_unstemmed | A HEALTH RELATED QUALITY OF LIFE AND PSYCHOPATHOLOGICAL SYMPTOMS IN PEOPLE WITH HEMOPHILIA, BLOODBORNE CO-INFECTIONS AND COMORBIDITIES: AN ITALIAN MULTICENTER OBSERVATIONAL STUDY |
| title_short | A HEALTH RELATED QUALITY OF LIFE AND PSYCHOPATHOLOGICAL SYMPTOMS IN PEOPLE WITH HEMOPHILIA, BLOODBORNE CO-INFECTIONS AND COMORBIDITIES: AN ITALIAN MULTICENTER OBSERVATIONAL STUDY |
| title_sort | health related quality of life and psychopathological symptoms in people with hemophilia bloodborne co infections and comorbidities an italian multicenter observational study |
| url | http://www.mjhid.org/index.php/mjhid/article/view/5153 |
| work_keys_str_mv | AT marioschiavoni ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT carlopruneti ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT saraguidotti ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT alessandramoscatello ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT francescagiordano ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT antonellacoluccia ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT ritacarlottasantoro ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT mariafrancescamansueto ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT eziozanon ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT renatomarino ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT isabellacantori ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT raimondodecristofaro ahealthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT marioschiavoni healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT carlopruneti healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT saraguidotti healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT alessandramoscatello healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT francescagiordano healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT antonellacoluccia healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT ritacarlottasantoro healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT mariafrancescamansueto healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT eziozanon healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT renatomarino healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT isabellacantori healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy AT raimondodecristofaro healthrelatedqualityoflifeandpsychopathologicalsymptomsinpeoplewithhemophiliabloodbornecoinfectionsandcomorbiditiesanitalianmulticenterobservationalstudy |