Raising the iron curtain: Lactate's secret role in oxidative stress defense
The hypothesis presented here is that certain cell types under oxidative stress, such as cancer cells, reprogram their metabolism to accumulate lactate, along with cytosolic Fe2+ within the labile iron pool, thereby establishing a metabolite-based H2O2 detoxification system. In this scenario, the Fe...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231725002678 |
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