Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast
Abstract Background Genetic information is stored on multiple chromosomes in eukaryotic organisms and is passed on to offspring through cell division. How chromosome number influences cell division and chromosome segregation is not yet understood. Results In this study, we use artificial chromosome-...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | Genome Biology |
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| Online Access: | https://doi.org/10.1186/s13059-025-03704-5 |
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| author | Yueyue Jiang Yanze Jian Lingyun Nie Xin Gu Ziyi Lu Yongkang Chu Xing Liu Xuebiao Yao Jin-Qiu Zhou Shengnan Zheng Chuanhai Fu |
| author_facet | Yueyue Jiang Yanze Jian Lingyun Nie Xin Gu Ziyi Lu Yongkang Chu Xing Liu Xuebiao Yao Jin-Qiu Zhou Shengnan Zheng Chuanhai Fu |
| author_sort | Yueyue Jiang |
| collection | DOAJ |
| description | Abstract Background Genetic information is stored on multiple chromosomes in eukaryotic organisms and is passed on to offspring through cell division. How chromosome number influences cell division and chromosome segregation is not yet understood. Results In this study, we use artificial chromosome-fusion fission yeast cells, which contain one or two chromosomes, as models to investigate the effects of a reduced chromosome number on mitosis and meiosis. In mitosis, chromosome number reduction, particularly full fusion into one chromosome, prolongs mitotic duration in a manner dependent on the spindle assembly checkpoint and improves chromosome segregation accuracy in spindle assembly checkpoint-deficient cells. By contrast, in meiosis, chromosome number reduction impairs prophase oscillatory nuclear movement, prolongs meiosis I duration but shortens meiosis II duration, and severely compromises meiosis I chromosome segregation. Conclusions Our work uncovers different effects of reduced chromosome number on mitotic and meiotic stability and offers insights into how organisms may select the appropriate number of chromosomes in evolution. |
| format | Article |
| id | doaj-art-cc4a8bc24c494c2c9b17c33f64ef18f5 |
| institution | Kabale University |
| issn | 1474-760X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Biology |
| spelling | doaj-art-cc4a8bc24c494c2c9b17c33f64ef18f52025-08-20T04:02:51ZengBMCGenome Biology1474-760X2025-08-0126111910.1186/s13059-025-03704-5Effects of chromosome number reduction on mitotic and meiotic stability in fission yeastYueyue Jiang0Yanze Jian1Lingyun Nie2Xin Gu3Ziyi Lu4Yongkang Chu5Xing Liu6Xuebiao Yao7Jin-Qiu Zhou8Shengnan Zheng9Chuanhai Fu10MOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaShanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaShanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaAbstract Background Genetic information is stored on multiple chromosomes in eukaryotic organisms and is passed on to offspring through cell division. How chromosome number influences cell division and chromosome segregation is not yet understood. Results In this study, we use artificial chromosome-fusion fission yeast cells, which contain one or two chromosomes, as models to investigate the effects of a reduced chromosome number on mitosis and meiosis. In mitosis, chromosome number reduction, particularly full fusion into one chromosome, prolongs mitotic duration in a manner dependent on the spindle assembly checkpoint and improves chromosome segregation accuracy in spindle assembly checkpoint-deficient cells. By contrast, in meiosis, chromosome number reduction impairs prophase oscillatory nuclear movement, prolongs meiosis I duration but shortens meiosis II duration, and severely compromises meiosis I chromosome segregation. Conclusions Our work uncovers different effects of reduced chromosome number on mitotic and meiotic stability and offers insights into how organisms may select the appropriate number of chromosomes in evolution.https://doi.org/10.1186/s13059-025-03704-5Chromosome numberFission yeastMitosisMeiosisSpindle assembly checkpoint |
| spellingShingle | Yueyue Jiang Yanze Jian Lingyun Nie Xin Gu Ziyi Lu Yongkang Chu Xing Liu Xuebiao Yao Jin-Qiu Zhou Shengnan Zheng Chuanhai Fu Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast Genome Biology Chromosome number Fission yeast Mitosis Meiosis Spindle assembly checkpoint |
| title | Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast |
| title_full | Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast |
| title_fullStr | Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast |
| title_full_unstemmed | Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast |
| title_short | Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast |
| title_sort | effects of chromosome number reduction on mitotic and meiotic stability in fission yeast |
| topic | Chromosome number Fission yeast Mitosis Meiosis Spindle assembly checkpoint |
| url | https://doi.org/10.1186/s13059-025-03704-5 |
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