Serum IL-23 levels reflect a myeloid inflammatory signature and predict the response to apremilast in patients with psoriatic arthritis

Serum IL-23 levels reflect a myeloid inflammatory signature and predict the response to apremilast in patients with psoriatic arthritis

BackgroundThe phosphodiesterase 4 (PDE4) inhibitor apremilast downregulates the production of IL-23 and other pro-inflammatory cytokines involved in the pathogenesis of psoriatic arthritis (PsA).AimTo investigate the effects of apremilast on the production of cytokines by peripheral blood monocyte-d...

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Bibliographic Details
Main Authors: Maria De Santis, Antonio Tonutti, Natasa Isailovic, Francesca Motta, Radu Marian Rivara, Rita Ragusa, Giacomo M. Guidelli, Marta Caprioli, Angela Ceribelli, Daniela Renna, Nicoletta Luciano, Carlo Selmi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
spondyloarthritis (including psoriatic arthritis)
precision medicine
immunology
cytokines
innate lymphocyte
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1455134/full
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