Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel
Introduction: Tridax procumbens (TP) has been used as an anticoagulant and wound healer. Known by other names as Tridax daisy or coatbuttons, TP belongs to flowering plant species of Asteraceae family. The current study is conducted to analyze the anti-inflammatory and antioxidant activity of TP lea...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1439_24 |
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| author | R. Nandita M. Jeevitha Kaarthikeyan Gurumoorthy Rajeshkumar Shanmugham Sudarsan Ravichandran Kethiswar Raj |
| author_facet | R. Nandita M. Jeevitha Kaarthikeyan Gurumoorthy Rajeshkumar Shanmugham Sudarsan Ravichandran Kethiswar Raj |
| author_sort | R. Nandita |
| collection | DOAJ |
| description | Introduction:
Tridax procumbens (TP) has been used as an anticoagulant and wound healer. Known by other names as Tridax daisy or coatbuttons, TP belongs to flowering plant species of Asteraceae family. The current study is conducted to analyze the anti-inflammatory and antioxidant activity of TP leaves extract-based chitosan (TPC) gel.
Materials and Methods:
Anti-inflammatory activity of TPC gel was assessed by bovine serum albumin (BSA) denaturation assay and egg albumin (EA) denaturation assay. Free radical scavenging activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and hydroxyl radical scavenging (H2O2) assay.
Results:
Both BSA and EA assay showed that the TPC gel (test gel) demonstrated maximum inhibition at 50 μL concentration and lowest inhibition at 10 μL similar to commercially available gel. The antioxidant activity assays revealed that both standard and the test gel exhibited high inhibitory percentage at all tested concentrations.
Conclusion:
The anti-inflammatory and antioxidant assay results demonstrate that the investigated compounds, notably TP leaves extract-based chitosan gel, have the potential to be effective agents in moderating oxidative stress and lowering inflammation. |
| format | Article |
| id | doaj-art-cc32f3960ac14fdc9f1c66e066d06ea3 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-cc32f3960ac14fdc9f1c66e066d06ea32025-01-13T11:04:54ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S4081S408410.4103/jpbs.jpbs_1439_24Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan GelR. NanditaM. JeevithaKaarthikeyan GurumoorthyRajeshkumar ShanmughamSudarsan RavichandranKethiswar RajIntroduction: Tridax procumbens (TP) has been used as an anticoagulant and wound healer. Known by other names as Tridax daisy or coatbuttons, TP belongs to flowering plant species of Asteraceae family. The current study is conducted to analyze the anti-inflammatory and antioxidant activity of TP leaves extract-based chitosan (TPC) gel. Materials and Methods: Anti-inflammatory activity of TPC gel was assessed by bovine serum albumin (BSA) denaturation assay and egg albumin (EA) denaturation assay. Free radical scavenging activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and hydroxyl radical scavenging (H2O2) assay. Results: Both BSA and EA assay showed that the TPC gel (test gel) demonstrated maximum inhibition at 50 μL concentration and lowest inhibition at 10 μL similar to commercially available gel. The antioxidant activity assays revealed that both standard and the test gel exhibited high inhibitory percentage at all tested concentrations. Conclusion: The anti-inflammatory and antioxidant assay results demonstrate that the investigated compounds, notably TP leaves extract-based chitosan gel, have the potential to be effective agents in moderating oxidative stress and lowering inflammation.https://journals.lww.com/10.4103/jpbs.jpbs_1439_24anti-inflammatoryantioxidantinnovativetridax procumbenswound-healing |
| spellingShingle | R. Nandita M. Jeevitha Kaarthikeyan Gurumoorthy Rajeshkumar Shanmugham Sudarsan Ravichandran Kethiswar Raj Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel Journal of Pharmacy and Bioallied Sciences anti-inflammatory antioxidant innovative tridax procumbens wound-healing |
| title | Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel |
| title_full | Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel |
| title_fullStr | Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel |
| title_full_unstemmed | Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel |
| title_short | Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel |
| title_sort | anti inflammatory activity and free radical scavenging activity of tridax procumbens leaves based chitosan gel |
| topic | anti-inflammatory antioxidant innovative tridax procumbens wound-healing |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1439_24 |
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