Artificial intelligence-based optimization for extracellular L-glutaminase free L-asparaginase production by Streptomyces violaceoruber under solid state fermentation conditions

Artificial intelligence-based optimization for extracellular L-glutaminase free L-asparaginase production by Streptomyces violaceoruber under solid state fermentation conditions

Abstract The bacterial L-asparaginase is a highly effective chemotherapeutic drug and a cornerstone of treatment protocols used for treatment the acute lymphoblastic leukemia in pediatric oncology. A potential actinomycete isolate, Streptomyces sp. strain NEAE-99, produces glutaminase-free L-asparag...

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Bibliographic Details
Main Authors: Noura El-Ahmady El-Naggar, Ragaa A. Hamouda, Naglaa Elshafey
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
L-asparaginase; Streptomyces; Identification
Optimization
Central composite design
Artificial neural network
Online Access:https://doi.org/10.1038/s41598-024-77867-9
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https://doi.org/10.1038/s41598-024-77867-9

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