Alteration of fractional anisotropy in preterm-born individuals: a systematic review and meta-analysis
Backgroud Neurological disorders are common in preterm (PT) born individuals. Diffusion tensor imaging (DTI) studies using tract-based spatial statistics (TBSS) effectively detect microstructural white matter (WM) abnormalities in the brain. We conducted this systematic review to integrate the findi...
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01443615.2024.2371956 |
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| author | Le Zhou Xinghui Liu Guolin He Meng Chen Shuai Zeng Chuntang Sun |
| author_facet | Le Zhou Xinghui Liu Guolin He Meng Chen Shuai Zeng Chuntang Sun |
| author_sort | Le Zhou |
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| description | Backgroud Neurological disorders are common in preterm (PT) born individuals. Diffusion tensor imaging (DTI) studies using tract-based spatial statistics (TBSS) effectively detect microstructural white matter (WM) abnormalities in the brain. We conducted this systematic review to integrate the findings of TBSS studies to determine the most consistent WM alterations in PT born individuals.Methods PubMed, Embase, Web of Science and Science Direct were searched. DTI studies using TBSS in PT born individuals were screened up to October 2022. The systematic review included studies reporting alterations in FA values for the entire brain in a stereotactic space, with three coordinates (x, y, z), according to the seed-based d mapping method.Results The search strategy identified seventeen studies that fulfilled our inclusion criteria, with a total of 911 PT-born individuals and 563 matched controls were analysed. Of the seventeen studies, eight were dedicated to 650 adults, five to 411 children and four to 413 infants. Ten studies recruited 812 individuals born very prematurely (GA <29 weeks), six studies recruited 386 moderately premature individuals (GA = 29–32 weeks) and one study recruited 276 individuals born late prematurely (GA >32 weeks). This meta-analysis of six studies including 388 individuals highlighted four brain regions in which fractional anisotropy (FA) was lower in PT group than in people born at term. The quantitative meta-analysis found that the most robust WM alterations were located in the corpus callosum (CC), the bilateral thalamus and the left superior longitudinal fasciculus (SLF) II. Significant changes in FA reflect WM abnormalities in PT born individuals from infant to young adulthood.Conclusions Significant changes in FA reflect WM abnormalities in individuals born PT from infancy to young adulthood. The abnormal development of the CC, bilateral thalamus and left SLF may play a vital role in the neurodevelopment of PT individuals. |
| format | Article |
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| institution | Kabale University |
| issn | 0144-3615 1364-6893 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj-art-cc12c7fa3d0e4e5ba35230bcb25e9da32025-01-09T12:13:17ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932024-12-0144110.1080/01443615.2024.2371956Alteration of fractional anisotropy in preterm-born individuals: a systematic review and meta-analysisLe Zhou0Xinghui Liu1Guolin He2Meng Chen3Shuai Zeng4Chuntang Sun5Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, P.R. ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, P.R. ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, P.R. ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, P.R. ChinaDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, P.R. ChinaBackgroud Neurological disorders are common in preterm (PT) born individuals. Diffusion tensor imaging (DTI) studies using tract-based spatial statistics (TBSS) effectively detect microstructural white matter (WM) abnormalities in the brain. We conducted this systematic review to integrate the findings of TBSS studies to determine the most consistent WM alterations in PT born individuals.Methods PubMed, Embase, Web of Science and Science Direct were searched. DTI studies using TBSS in PT born individuals were screened up to October 2022. The systematic review included studies reporting alterations in FA values for the entire brain in a stereotactic space, with three coordinates (x, y, z), according to the seed-based d mapping method.Results The search strategy identified seventeen studies that fulfilled our inclusion criteria, with a total of 911 PT-born individuals and 563 matched controls were analysed. Of the seventeen studies, eight were dedicated to 650 adults, five to 411 children and four to 413 infants. Ten studies recruited 812 individuals born very prematurely (GA <29 weeks), six studies recruited 386 moderately premature individuals (GA = 29–32 weeks) and one study recruited 276 individuals born late prematurely (GA >32 weeks). This meta-analysis of six studies including 388 individuals highlighted four brain regions in which fractional anisotropy (FA) was lower in PT group than in people born at term. The quantitative meta-analysis found that the most robust WM alterations were located in the corpus callosum (CC), the bilateral thalamus and the left superior longitudinal fasciculus (SLF) II. Significant changes in FA reflect WM abnormalities in PT born individuals from infant to young adulthood.Conclusions Significant changes in FA reflect WM abnormalities in individuals born PT from infancy to young adulthood. The abnormal development of the CC, bilateral thalamus and left SLF may play a vital role in the neurodevelopment of PT individuals.https://www.tandfonline.com/doi/10.1080/01443615.2024.2371956Diffusion tensor imaging (DTI)tract-based spatial statistics (TBSS)preterm bornvoxel-based morphometry (VBM)seed-based d mapping (SDM) |
| spellingShingle | Le Zhou Xinghui Liu Guolin He Meng Chen Shuai Zeng Chuntang Sun Alteration of fractional anisotropy in preterm-born individuals: a systematic review and meta-analysis Journal of Obstetrics and Gynaecology Diffusion tensor imaging (DTI) tract-based spatial statistics (TBSS) preterm born voxel-based morphometry (VBM) seed-based d mapping (SDM) |
| title | Alteration of fractional anisotropy in preterm-born individuals: a systematic review and meta-analysis |
| title_full | Alteration of fractional anisotropy in preterm-born individuals: a systematic review and meta-analysis |
| title_fullStr | Alteration of fractional anisotropy in preterm-born individuals: a systematic review and meta-analysis |
| title_full_unstemmed | Alteration of fractional anisotropy in preterm-born individuals: a systematic review and meta-analysis |
| title_short | Alteration of fractional anisotropy in preterm-born individuals: a systematic review and meta-analysis |
| title_sort | alteration of fractional anisotropy in preterm born individuals a systematic review and meta analysis |
| topic | Diffusion tensor imaging (DTI) tract-based spatial statistics (TBSS) preterm born voxel-based morphometry (VBM) seed-based d mapping (SDM) |
| url | https://www.tandfonline.com/doi/10.1080/01443615.2024.2371956 |
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