Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis
BackgroundAmmonia (NH3) and hydrogen sulfide (H2S) are produced during digestion in the human gut, yet the impact of these internally generated gases on male reproduction have received limited attention in scientific research.MethodsWe systematically reviewed 935 scientific publications, spanning fr...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1449453/full |
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| author | Yanan Hao Yanan Hao Yanan Hao Xin Du Chang Cai Yong Zhao Yonglin Ren |
| author_facet | Yanan Hao Yanan Hao Yanan Hao Xin Du Chang Cai Yong Zhao Yonglin Ren |
| author_sort | Yanan Hao |
| collection | DOAJ |
| description | BackgroundAmmonia (NH3) and hydrogen sulfide (H2S) are produced during digestion in the human gut, yet the impact of these internally generated gases on male reproduction have received limited attention in scientific research.MethodsWe systematically reviewed 935 scientific publications, spanning from 1947 to 2023, focusing on external or internal NH3 and/or H2S, male infertility, and gut microbiota. Meta-analysis was conducted to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs) of combined studies.ResultsOur findings revealed that the internal NH3 and/or H2S were negatively related to the Lactobacillus, which is beneficial to male fertility, whereas NH3 and H2S were positively related to Bacteroides, which showed negative effects on male fertility. The meta-analysis comparing Lactobacillus and Bacteroides levels with NH3 showed statistically significant results (p<0.001).ConclusionsThe meta-analysis is the first to confirm these facts and explored the potential existence of a gut microbiota-inner gases-male fertility axis in the human gut. |
| format | Article |
| id | doaj-art-cc112fd742ab48fab0607cd165991af2 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-cc112fd742ab48fab0607cd165991af22025-01-06T06:59:24ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.14494531449453Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysisYanan Hao0Yanan Hao1Yanan Hao2Xin Du3Chang Cai4Yong Zhao5Yonglin Ren6The Institute of Brain Science and Brain-inspired Research, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaCollege of Environmental and Life Sciences, Murdoch University, Perth, WA, AustraliaCollege of Life Sciences, Qingdao Agricultural University, Qingdao, ChinaCollege of Environmental and Life Sciences, Murdoch University, Perth, WA, AustraliaCollege of Environmental and Life Sciences, Murdoch University, Perth, WA, AustraliaState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaCollege of Environmental and Life Sciences, Murdoch University, Perth, WA, AustraliaBackgroundAmmonia (NH3) and hydrogen sulfide (H2S) are produced during digestion in the human gut, yet the impact of these internally generated gases on male reproduction have received limited attention in scientific research.MethodsWe systematically reviewed 935 scientific publications, spanning from 1947 to 2023, focusing on external or internal NH3 and/or H2S, male infertility, and gut microbiota. Meta-analysis was conducted to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs) of combined studies.ResultsOur findings revealed that the internal NH3 and/or H2S were negatively related to the Lactobacillus, which is beneficial to male fertility, whereas NH3 and H2S were positively related to Bacteroides, which showed negative effects on male fertility. The meta-analysis comparing Lactobacillus and Bacteroides levels with NH3 showed statistically significant results (p<0.001).ConclusionsThe meta-analysis is the first to confirm these facts and explored the potential existence of a gut microbiota-inner gases-male fertility axis in the human gut.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1449453/fullammoniahydrogen sulfidegut microbiotamale infertilityinternal gases |
| spellingShingle | Yanan Hao Yanan Hao Yanan Hao Xin Du Chang Cai Yong Zhao Yonglin Ren Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis Frontiers in Cellular and Infection Microbiology ammonia hydrogen sulfide gut microbiota male infertility internal gases |
| title | Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis |
| title_full | Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis |
| title_fullStr | Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis |
| title_full_unstemmed | Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis |
| title_short | Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis |
| title_sort | ammonia and hydrogen sulfide new insights into gut microbiota and male infertility through meta analysis |
| topic | ammonia hydrogen sulfide gut microbiota male infertility internal gases |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1449453/full |
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