Animal models of cochlear implant: Classification and update
Cochlear implantation (CI) is currently recognized as the most effective treatment for severe to profound sensorineural deafness and is considered one of the most successful neural prostheses. Since its inception in 1961, cochlear implantation has expanded its range of applications to encompass youn...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-07-01
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| Series: | Journal of Otology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672293024000230 |
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| _version_ | 1846139907701997568 |
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| author | Haiqiao Du Jianan Li Wei Chen Weiwei Guo Shiming Yang |
| author_facet | Haiqiao Du Jianan Li Wei Chen Weiwei Guo Shiming Yang |
| author_sort | Haiqiao Du |
| collection | DOAJ |
| description | Cochlear implantation (CI) is currently recognized as the most effective treatment for severe to profound sensorineural deafness and is considered one of the most successful neural prostheses. Since its inception in 1961, cochlear implantation has expanded its range of applications to encompass younger newborns, older people, and individuals with unilateral hearing loss. In addition, it has improved its surgical methods to minimize the occurrence of complications. Furthermore, notable advancements have been made in the design of electrodes, techniques for speech processing, and software for programming. Nevertheless, inflammation, fibrosis, and even ossification are observed in the cochlea of nearly all cochlear implant (CI) patients. These tissue responses might have a negative impact on the performance of the implants, residual hearing, and the results of post-operative CI rehabilitation. Animal models are significant translational tools that offer essential preclinical data for possible therapeutics. Thus, this study concentrates on the existing animal models used for cochlear implantation, highlights the advancements made in research, and offers insights into potential future research areas. |
| format | Article |
| id | doaj-art-cc0949ad0cae44dc90b1e910ef8ac729 |
| institution | Kabale University |
| issn | 1672-2930 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Otology |
| spelling | doaj-art-cc0949ad0cae44dc90b1e910ef8ac7292024-12-06T05:13:08ZengElsevierJournal of Otology1672-29302024-07-01193173177Animal models of cochlear implant: Classification and updateHaiqiao Du0Jianan Li1Wei Chen2Weiwei Guo3Shiming Yang4Department of Otolaryngology-Head & Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China; State Key Laboratory of Hearing and Balance Science, Beijing, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China; Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, ChinaDepartment of Otolaryngology-Head & Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China; State Key Laboratory of Hearing and Balance Science, Beijing, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China; Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, ChinaDepartment of Otolaryngology-Head & Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China; State Key Laboratory of Hearing and Balance Science, Beijing, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China; Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, ChinaDepartment of Otolaryngology-Head & Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China; State Key Laboratory of Hearing and Balance Science, Beijing, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China; Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, ChinaDepartment of Otolaryngology-Head & Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China; State Key Laboratory of Hearing and Balance Science, Beijing, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China; Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China; Corresponding author. Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, China.Cochlear implantation (CI) is currently recognized as the most effective treatment for severe to profound sensorineural deafness and is considered one of the most successful neural prostheses. Since its inception in 1961, cochlear implantation has expanded its range of applications to encompass younger newborns, older people, and individuals with unilateral hearing loss. In addition, it has improved its surgical methods to minimize the occurrence of complications. Furthermore, notable advancements have been made in the design of electrodes, techniques for speech processing, and software for programming. Nevertheless, inflammation, fibrosis, and even ossification are observed in the cochlea of nearly all cochlear implant (CI) patients. These tissue responses might have a negative impact on the performance of the implants, residual hearing, and the results of post-operative CI rehabilitation. Animal models are significant translational tools that offer essential preclinical data for possible therapeutics. Thus, this study concentrates on the existing animal models used for cochlear implantation, highlights the advancements made in research, and offers insights into potential future research areas.http://www.sciencedirect.com/science/article/pii/S1672293024000230Cochlear implantationAnimal modelsForeign body responseFibrosisResidual hearing |
| spellingShingle | Haiqiao Du Jianan Li Wei Chen Weiwei Guo Shiming Yang Animal models of cochlear implant: Classification and update Journal of Otology Cochlear implantation Animal models Foreign body response Fibrosis Residual hearing |
| title | Animal models of cochlear implant: Classification and update |
| title_full | Animal models of cochlear implant: Classification and update |
| title_fullStr | Animal models of cochlear implant: Classification and update |
| title_full_unstemmed | Animal models of cochlear implant: Classification and update |
| title_short | Animal models of cochlear implant: Classification and update |
| title_sort | animal models of cochlear implant classification and update |
| topic | Cochlear implantation Animal models Foreign body response Fibrosis Residual hearing |
| url | http://www.sciencedirect.com/science/article/pii/S1672293024000230 |
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