Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review
Acne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit. Many studies have reported that people with AV have higher levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) compared to healthy controls. Hence, they concluded...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1538373/full |
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| author | Liang Wu Sheng-Cai Zhu Yang He Yun-Xia Zhu Xiao-Liang Ou-Yang Deng Zhang Chun-Ming Li |
| author_facet | Liang Wu Sheng-Cai Zhu Yang He Yun-Xia Zhu Xiao-Liang Ou-Yang Deng Zhang Chun-Ming Li |
| author_sort | Liang Wu |
| collection | DOAJ |
| description | Acne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit. Many studies have reported that people with AV have higher levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) compared to healthy controls. Hence, they concluded that an unhealthy lipid profile is an independent risk factor for AV. Recent research in metabolomics and lipidomics has been propelled by rapid advancements in technologies including computational methods and mass spectrometry. Using metabolomics and lipidomics approach, a broad range of structurally diverse lipid species were detected and important lipid biomarkers were identified that are vital to the pathogenesis of AV. In this review, we will describe the recent progress in dyslipidemia of AV using metabolomics and lipidomics advances. We will begin with a literature overview of dyslipidemia of AV, followed by a short introduction of metabolomics and lipidomics. Finally, we will focus on applying metabolomics and lipidomics in dyslipidemia of AV. |
| format | Article |
| id | doaj-art-cbed5114332840b384cb0cf9eb9b17e7 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-cbed5114332840b384cb0cf9eb9b17e72025-01-15T05:11:08ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15383731538373Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini reviewLiang Wu0Sheng-Cai Zhu1Yang He2Yun-Xia Zhu3Xiao-Liang Ou-Yang4Deng Zhang5Chun-Ming Li6Department of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Dermatology, The Fifth People's Hospital Affiliated to Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaAcne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit. Many studies have reported that people with AV have higher levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) compared to healthy controls. Hence, they concluded that an unhealthy lipid profile is an independent risk factor for AV. Recent research in metabolomics and lipidomics has been propelled by rapid advancements in technologies including computational methods and mass spectrometry. Using metabolomics and lipidomics approach, a broad range of structurally diverse lipid species were detected and important lipid biomarkers were identified that are vital to the pathogenesis of AV. In this review, we will describe the recent progress in dyslipidemia of AV using metabolomics and lipidomics advances. We will begin with a literature overview of dyslipidemia of AV, followed by a short introduction of metabolomics and lipidomics. Finally, we will focus on applying metabolomics and lipidomics in dyslipidemia of AV.https://www.frontiersin.org/articles/10.3389/fmed.2024.1538373/fullacne vulgarisdyslipidemiametabolomicslipidomicssphingomyelinsphosphatidylcholines |
| spellingShingle | Liang Wu Sheng-Cai Zhu Yang He Yun-Xia Zhu Xiao-Liang Ou-Yang Deng Zhang Chun-Ming Li Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review Frontiers in Medicine acne vulgaris dyslipidemia metabolomics lipidomics sphingomyelins phosphatidylcholines |
| title | Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review |
| title_full | Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review |
| title_fullStr | Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review |
| title_full_unstemmed | Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review |
| title_short | Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review |
| title_sort | current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris a mini review |
| topic | acne vulgaris dyslipidemia metabolomics lipidomics sphingomyelins phosphatidylcholines |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1538373/full |
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