Assessing expression patterns of PTGR1, a potential biomarker for acylfulven sensitivity in urothelial carcinoma

Assessing expression patterns of PTGR1, a potential biomarker for acylfulven sensitivity in urothelial carcinoma

Abstract Background Metastatic urothelial carcinoma (mUC) has a poor prognosis, despite recent therapeutic advancements. Prostaglandin Reductase 1 (PTGR1) is essential for activating acylfulvens, a promising class of drugs for treating a subset of urothelial carcinoma (UC) patients. The efficacy of...

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Main Authors: Dag Rune Stormoen, Signe Lehn, Kent W. Mouw, Zoltan Szallasi, Linea Cecilie Melchior, Line Hammer Dohn, Judit Börcsok, Maria Rossing, Birgitte Grønkaer Toft, Helle Pappot
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Bladder cancer
Urothelial cancer
Biomarker
Validation study
DNA repair deficiency
PTGR1
Online Access:https://doi.org/10.1038/s41598-024-79334-x
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