Heart over mind: metabolic control of white adipose tissue and liver
Abstract Increasing evidence suggests that the heart controls the metabolism of peripheral organs. Olson and colleagues previously demonstrated that miR‐208a controls systemic energy homeostasis through the regulation of MED13 in cardiomyocytes (Grueter et al, 2012). In their follow‐up study in this...
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| Format: | Article |
| Language: | English |
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Springer Nature
2014-12-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.201404749 |
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| author | Michinari Nakamura Junichi Sadoshima |
| author_facet | Michinari Nakamura Junichi Sadoshima |
| author_sort | Michinari Nakamura |
| collection | DOAJ |
| description | Abstract Increasing evidence suggests that the heart controls the metabolism of peripheral organs. Olson and colleagues previously demonstrated that miR‐208a controls systemic energy homeostasis through the regulation of MED13 in cardiomyocytes (Grueter et al, 2012). In their follow‐up study in this issue of EMBO Molecular Medicine, white adipose tissue (WAT) and liver are identified as the physiological targets of cardiac MED13 signaling, most likely through cardiac‐derived circulating factors, which boost energy consumption by upregulating metabolic gene expression and increasing mitochondrial numbers (Baskin et al, 2014). In turn, increased energy expenditure in WAT and the liver confers leanness. These findings strengthen the evidence of metabolic crosstalk between the heart and peripheral tissues through cardiokines and also set the stage for the development of novel treatments for metabolic syndrome. |
| format | Article |
| id | doaj-art-cbc0a2c2d30e401b8e79c9b8224bb00f |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-cbc0a2c2d30e401b8e79c9b8224bb00f2025-08-20T04:02:56ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842014-12-016121521152410.15252/emmm.201404749Heart over mind: metabolic control of white adipose tissue and liverMichinari Nakamura0Junichi Sadoshima1Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers‐New Jersey Medical SchoolDepartment of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers‐New Jersey Medical SchoolAbstract Increasing evidence suggests that the heart controls the metabolism of peripheral organs. Olson and colleagues previously demonstrated that miR‐208a controls systemic energy homeostasis through the regulation of MED13 in cardiomyocytes (Grueter et al, 2012). In their follow‐up study in this issue of EMBO Molecular Medicine, white adipose tissue (WAT) and liver are identified as the physiological targets of cardiac MED13 signaling, most likely through cardiac‐derived circulating factors, which boost energy consumption by upregulating metabolic gene expression and increasing mitochondrial numbers (Baskin et al, 2014). In turn, increased energy expenditure in WAT and the liver confers leanness. These findings strengthen the evidence of metabolic crosstalk between the heart and peripheral tissues through cardiokines and also set the stage for the development of novel treatments for metabolic syndrome.https://doi.org/10.15252/emmm.201404749 |
| spellingShingle | Michinari Nakamura Junichi Sadoshima Heart over mind: metabolic control of white adipose tissue and liver EMBO Molecular Medicine |
| title | Heart over mind: metabolic control of white adipose tissue and liver |
| title_full | Heart over mind: metabolic control of white adipose tissue and liver |
| title_fullStr | Heart over mind: metabolic control of white adipose tissue and liver |
| title_full_unstemmed | Heart over mind: metabolic control of white adipose tissue and liver |
| title_short | Heart over mind: metabolic control of white adipose tissue and liver |
| title_sort | heart over mind metabolic control of white adipose tissue and liver |
| url | https://doi.org/10.15252/emmm.201404749 |
| work_keys_str_mv | AT michinarinakamura heartovermindmetaboliccontrolofwhiteadiposetissueandliver AT junichisadoshima heartovermindmetaboliccontrolofwhiteadiposetissueandliver |