Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia

Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia

Abstract: In acute lymphoblastic leukemia (ALL), the B-cell lymphoma 2 inhibitor venetoclax may enhance the efficacy of chemotherapy, allowing dose reductions. This phase 1b study of venetoclax plus attenuated chemotherapy enrolled 19 patients with ALL either newly diagnosed (aged ≥60 years, n = 11...

Full description

Saved in:

Bibliographic Details
Main Authors:	Marlise R. Luskin, Shai Shimony, Julia Keating, Eric S. Winer, Jacqueline S. Garcia, Richard M. Stone, Elias Jabbour, Yael Flamand, Kristen Stevenson, Jeremy Ryan, Zhihong Zeng, Anthony Letai, Marina Konopleva, Nitin Jain, Daniel J. DeAngelo
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Series:	Blood Advances
Online Access:	http://www.sciencedirect.com/science/article/pii/S2473952924006554
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Treatment with obinutuzumab plus venetoclax reshapes the TRB repertoire of CLL patients
by: Paul J. Hengeveld, et al.
Published: (2025-01-01)

An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma
by: Prajwal Boddu, et al.
Published: (2017-01-01)

Hemophagocytic lymphohistiocytosis secondary to refractory acute myeloid leukemia resolved after second line treatment with azacitidine plus venetoclax
by: Claudio Fozza
Published: (2024-01-01)

Venetoclax in combination with chidamide and azacitidine for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia with the MLL-AF4 gene: a case report and literature review
by: Xuelian Jin, et al.
Published: (2025-01-01)

Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax
by: Waqas Jehangir, et al.
Published: (2020-01-01)

Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia
by: Renshi Kawakatsu, et al.
Published: (2025-01-01)

Investigating resistance to 5-Azacytidine and Venetoclax in PDX models of MDS/AML
by: Petra Bašová, et al.
Published: (2025-01-01)

Relapsed childhood T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma
by: Andrew D. Hughes, et al.
Published: (2025-01-01)

Real-life outcome after failure to venetoclax and hypomethylating-based therapy for acute myeloid leukemia
by: Carlos Jiménez-Vicente, et al.
Published: (2025-01-01)

Osteoporosis in Acute Lymphoblastic Leukemia
by: Lestry Fibriani, et al.
Published: (2019-09-01)

Venetoclax added to CLAG regimen might improve the outcome of patients with relapsed/refractory acute myeloid leukemia
by: Yu Zhang, et al.
Published: (2025-02-01)

Venetoclax-based salvage therapy as a bridge to transplant is feasible and effective in patients with relapsed/refractory AML
by: Julia M. Unglaub, et al.
Published: (2025-01-01)

Age-Adjusted Schedules of Venetoclax and Hypomethylating Agents to Treat Extremely Elderly Patients with Acute Myeloid Leukemia
by: Aaron M. Lee, et al.
Published: (2022-01-01)

Single-center experience of venetoclax combined with azacitidine in young patients with newly diagnosed acute myeloid leukemia
by: Xuezhu Xu, et al.
Published: (2025-01-01)

ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress
by: Jenna L. Carter, et al.
Published: (2025-01-01)

COVID-19 in patients with chronic lymphocytic leukemia treated with venetoclax: what is the role of anti-CD20 antibody?
by: Francesco Autore, et al.
Published: (2025-01-01)

Secondary neoplasms in survivors of pediatric acute lymphoblastic leukemia and lymphoblastic lymphoma: a single-center, retrospective study
by: Eri Ushida, et al.
Published: (2025-01-01)

Acute Neurotoxicity in Children Treated for Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma: A 10-Year Single-Centre Experience
by: Izabela Kranjčec, et al.
Published: (2024-12-01)

Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention
by: Rodrigo Fonseca, et al.
Published: (2025-02-01)

Precursor B Lymphoblastic Lymphoma Involving the Stomach
by: Masaya Iwamuro, et al.
Published: (2013-01-01)

Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma
by: Kayo Tokeji, et al.
Published: (2016-01-01)

Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax
by: Caroline A. Coughlin, et al.
Published: (2025-02-01)

Left Kidney Undifferentiated Spindle Cell Sarcoma with Myeloid Cell Leukemia-1 Amplification: Therapeutic Response to Bortezomib, Venetoclax, and Dexamethasone Therapy
by: Cheng-Yu Tang, et al.
Published: (2023-10-01)

The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute lymphoblastic leukemia
by: Xiaoxia Wu, et al.
Published: (2024-09-01)

Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction Chemotherapy
by: Musa Fares Alzahrani
Published: (2024-12-01)

Une diffusion de plus en plus large
by: Esther Cloutier
Published: (2004-05-01)

Differential Regulation of NK Cell Receptors in Acute Lymphoblastic Leukemia
by: Le Jie Lee, et al.
Published: (2022-01-01)

Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient
by: Ryan A. Denu, et al.
Published: (2019-01-01)

Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation
by: Eric Moughames, et al.
Published: (2019-01-01)

Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia
by: Stephen E. Langabeer, et al.
Published: (2016-01-01)

Flow Cytometric DNA Index and Karyotype in Childhood Lymphoblastic Leukemia
by: Erik Forestier, et al.
Published: (1998-01-01)

An Unusual Presentation of T-Cell Lymphoblastic Lymphoma with Isolated Renal Involvement
by: Sultan Aydın Köker, et al.
Published: (2019-01-01)

Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia
by: Terrie Flatt, et al.
Published: (2012-01-01)

Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure
by: Ashley Rose, et al.
Published: (2019-01-01)

An Adult Patient with Systemic Mastocytosis and B-Acute Lymphoblastic Leukemia
by: Theodoros Iliakis, et al.
Published: (2014-01-01)

Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia
by: Fabian Lang, et al.
Published: (2015-01-01)

Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression
by: Georgia Tsaouli, et al.
Published: (2019-01-01)

CAR-T CELL THERAPY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
by: Ugo Testa, et al.
Published: (2024-01-01)

Coexistence of T-Cell Lymphoblastic Lymphoma and Ichthyosis Vulgaris: A Case Report
by: Şule Çalışkan Kamış, et al.
Published: (2025-01-01)

A Chinese Child Presented with Early T Cell Precursor Lymphoblastic Lymphoma
by: Xiangyang Pu, et al.
Published: (2021-01-01)