Do domain-specific protein language models outperform general models on immunology-related tasks?
Deciphering the antigen recognition capabilities by T-cell and B-cell receptors (antibodies) is essential for advancing our understanding of adaptive immune system responses. In recent years, the development of protein language models (PLMs) has facilitated the development of bioinformatic pipelines...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | ImmunoInformatics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667119024000065 |
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| author | Nicolas Deutschmann Aurelien Pelissier Anna Weber Shuaijun Gao Jasmina Bogojeska María Rodríguez Martínez |
| author_facet | Nicolas Deutschmann Aurelien Pelissier Anna Weber Shuaijun Gao Jasmina Bogojeska María Rodríguez Martínez |
| author_sort | Nicolas Deutschmann |
| collection | DOAJ |
| description | Deciphering the antigen recognition capabilities by T-cell and B-cell receptors (antibodies) is essential for advancing our understanding of adaptive immune system responses. In recent years, the development of protein language models (PLMs) has facilitated the development of bioinformatic pipelines where complex amino acid sequences are transformed into vectorized embeddings, which are then applied to a range of downstream analytical tasks. With their success, we have witnessed the emergence of domain-specific PLMs tailored to specific proteins, such as immune receptors. Domain-specific models are often assumed to possess enhanced representation capabilities for targeted applications, however, this assumption has not been thoroughly evaluated. In this manuscript, we assess the efficacy of both generalist and domain-specific transformer-based embeddings in characterizing B and T-cell receptors. Specifically, we assess the accuracy of models that leverage these embeddings to predict antigen specificity and elucidate the evolutionary changes that B cells undergo during an immune response. We demonstrate that the prevailing notion of domain-specific models outperforming general models requires a more nuanced examination. We also observe remarkable differences between generalist and domain-specific PLMs, not only in terms of performance but also in the manner they encode information. Finally, we observe that the choice of the size and the embedding layer in PLMs are essential model hyperparameters in different tasks. Overall, our analyzes reveal the promising potential of PLMs in modeling protein function while providing insights into their information-handling capabilities. We also discuss the crucial factors that should be taken into account when selecting a PLM tailored to a particular task. |
| format | Article |
| id | doaj-art-cbb416f70c1f4b99ada1a4eeb87b9e28 |
| institution | Kabale University |
| issn | 2667-1190 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | ImmunoInformatics |
| spelling | doaj-art-cbb416f70c1f4b99ada1a4eeb87b9e282025-01-10T04:38:26ZengElsevierImmunoInformatics2667-11902024-06-0114100036Do domain-specific protein language models outperform general models on immunology-related tasks?Nicolas Deutschmann0Aurelien Pelissier1Anna Weber2Shuaijun Gao3Jasmina Bogojeska4María Rodríguez Martínez5IBM Research Europe, 8803 Rüschlikon, SwitzerlandIBM Research Europe, 8803 Rüschlikon, Switzerland; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland; Institute of Computational Life Sciences, Zürich University of Applied Sciences (ZHAW), 8820 Wädenswil, SwitzerlandIBM Research Europe, 8803 Rüschlikon, Switzerland; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, SwitzerlandIBM Research Europe, 8803 Rüschlikon, SwitzerlandIBM Research Europe, 8803 Rüschlikon, SwitzerlandIBM Research Europe, 8803 Rüschlikon, Switzerland; Correspondence to: Yale School of Medicine, 06510 New Haven, United States.Deciphering the antigen recognition capabilities by T-cell and B-cell receptors (antibodies) is essential for advancing our understanding of adaptive immune system responses. In recent years, the development of protein language models (PLMs) has facilitated the development of bioinformatic pipelines where complex amino acid sequences are transformed into vectorized embeddings, which are then applied to a range of downstream analytical tasks. With their success, we have witnessed the emergence of domain-specific PLMs tailored to specific proteins, such as immune receptors. Domain-specific models are often assumed to possess enhanced representation capabilities for targeted applications, however, this assumption has not been thoroughly evaluated. In this manuscript, we assess the efficacy of both generalist and domain-specific transformer-based embeddings in characterizing B and T-cell receptors. Specifically, we assess the accuracy of models that leverage these embeddings to predict antigen specificity and elucidate the evolutionary changes that B cells undergo during an immune response. We demonstrate that the prevailing notion of domain-specific models outperforming general models requires a more nuanced examination. We also observe remarkable differences between generalist and domain-specific PLMs, not only in terms of performance but also in the manner they encode information. Finally, we observe that the choice of the size and the embedding layer in PLMs are essential model hyperparameters in different tasks. Overall, our analyzes reveal the promising potential of PLMs in modeling protein function while providing insights into their information-handling capabilities. We also discuss the crucial factors that should be taken into account when selecting a PLM tailored to a particular task.http://www.sciencedirect.com/science/article/pii/S2667119024000065Large Language ModelProtein Language ModelT cellB cellEvolutionAffinity |
| spellingShingle | Nicolas Deutschmann Aurelien Pelissier Anna Weber Shuaijun Gao Jasmina Bogojeska María Rodríguez Martínez Do domain-specific protein language models outperform general models on immunology-related tasks? ImmunoInformatics Large Language Model Protein Language Model T cell B cell Evolution Affinity |
| title | Do domain-specific protein language models outperform general models on immunology-related tasks? |
| title_full | Do domain-specific protein language models outperform general models on immunology-related tasks? |
| title_fullStr | Do domain-specific protein language models outperform general models on immunology-related tasks? |
| title_full_unstemmed | Do domain-specific protein language models outperform general models on immunology-related tasks? |
| title_short | Do domain-specific protein language models outperform general models on immunology-related tasks? |
| title_sort | do domain specific protein language models outperform general models on immunology related tasks |
| topic | Large Language Model Protein Language Model T cell B cell Evolution Affinity |
| url | http://www.sciencedirect.com/science/article/pii/S2667119024000065 |
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