Elevated levels of serum PKM2, Gal-3 and CitH3 could predict pulmonary infection complicated by mechanical ventilation
Objective To investigate the relationship between serum level of pyruvate kinase M2 (PKM2), galectin-3(Gal-3) and citrolinated histone H3 (CitH3) and pulmonary infection in patients with mechanical ventilation (MV). Methods A total of 120 patients with MV admitted to Jinhua Central Hospital from O...
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2025-01-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-1-86.pdf |
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| author | HUANG Hangdong, LI Danyu, ZHU Xiaofeng |
| author_facet | HUANG Hangdong, LI Danyu, ZHU Xiaofeng |
| author_sort | HUANG Hangdong, LI Danyu, ZHU Xiaofeng |
| collection | DOAJ |
| description | Objective To investigate the relationship between serum level of pyruvate kinase M2 (PKM2), galectin-3(Gal-3) and citrolinated histone H3 (CitH3) and pulmonary infection in patients with mechanical ventilation (MV). Methods A total of 120 patients with MV admitted to Jinhua Central Hospital from October 2022 to March 2024 were included in the study. They were divided into pulmonary infection group (n=50) and non-pulmonary infection group (n=70). Serum level of PKM2, Gal-3 and CitH3 was detected by ELISA. The patients were divided into good prognosis group (n=79) and bad prognosis group (n=41). Multivariate Logistic regression analysis was performed to analyze the factors affecting the adverse prognosis of MV patients. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum PKM2, Gal-3 and CitH3 for poor prognosis in patients undergoing MV. Results Compared with non-pulmonary infection group, serum level of PKM2, Gal-3 and CitH3 in pulmonary infection group was increased (P＜0.05). The level of serum PKM2, Gal-3 and CitH3 in the poor prognosis group was increased (P＜0.05). The Clinical Pulmonary Infection score (CPIS) of the poor prognosis group was higher than that of the good prognosis group (P＜0.05). PKM2, Gal-3 and CitH3 were all risk factors for poor prognosis in MV patients (P＜0.05). The area under the curve (AUC) of PKM2, Gal-3, CitH3 and combined prediction of poor prognosis were 0.712, 0.839, 0.779 and 0.925, respectively. AUC of combined diagnosis of PKM2, GAL-3, CITH3 and combined diagnosis was better than that of single detection (Z=4.261, 2.521, 3.676, P＜0.001, 0.05, 0.001). Conclusions The serum level of PKM2, Gal-3, and CitH3 in MV patients with concurrent pulmonary infections is found to be higher than those in those without pulmonary infections, so these three factors have potential predictive value for poor prognosis of MV patients. |
| format | Article |
| id | doaj-art-cba37c1c1e8d43c9aedbe54df037dba0 |
| institution | Kabale University |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj-art-cba37c1c1e8d43c9aedbe54df037dba02025-08-20T03:44:35ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252025-01-01451869010.16352/j.issn.1001-6325.2025.01.0086Elevated levels of serum PKM2, Gal-3 and CitH3 could predict pulmonary infection complicated by mechanical ventilationHUANG Hangdong, LI Danyu, ZHU Xiaofeng0Department of Intensive Care, Jinhua Central Hospital, Jinhua 321000, ChinaObjective To investigate the relationship between serum level of pyruvate kinase M2 (PKM2), galectin-3(Gal-3) and citrolinated histone H3 (CitH3) and pulmonary infection in patients with mechanical ventilation (MV). Methods A total of 120 patients with MV admitted to Jinhua Central Hospital from October 2022 to March 2024 were included in the study. They were divided into pulmonary infection group (n=50) and non-pulmonary infection group (n=70). Serum level of PKM2, Gal-3 and CitH3 was detected by ELISA. The patients were divided into good prognosis group (n=79) and bad prognosis group (n=41). Multivariate Logistic regression analysis was performed to analyze the factors affecting the adverse prognosis of MV patients. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum PKM2, Gal-3 and CitH3 for poor prognosis in patients undergoing MV. Results Compared with non-pulmonary infection group, serum level of PKM2, Gal-3 and CitH3 in pulmonary infection group was increased (P＜0.05). The level of serum PKM2, Gal-3 and CitH3 in the poor prognosis group was increased (P＜0.05). The Clinical Pulmonary Infection score (CPIS) of the poor prognosis group was higher than that of the good prognosis group (P＜0.05). PKM2, Gal-3 and CitH3 were all risk factors for poor prognosis in MV patients (P＜0.05). The area under the curve (AUC) of PKM2, Gal-3, CitH3 and combined prediction of poor prognosis were 0.712, 0.839, 0.779 and 0.925, respectively. AUC of combined diagnosis of PKM2, GAL-3, CITH3 and combined diagnosis was better than that of single detection (Z=4.261, 2.521, 3.676, P＜0.001, 0.05, 0.001). Conclusions The serum level of PKM2, Gal-3, and CitH3 in MV patients with concurrent pulmonary infections is found to be higher than those in those without pulmonary infections, so these three factors have potential predictive value for poor prognosis of MV patients.https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-1-86.pdfmechanical ventilation|pulmonary infection|pyruvate kinase m2(pkm2)|galectin-3(gal-3)|citrullinated histone h3(cith3)|prognosis |
| spellingShingle | HUANG Hangdong, LI Danyu, ZHU Xiaofeng Elevated levels of serum PKM2, Gal-3 and CitH3 could predict pulmonary infection complicated by mechanical ventilation Jichu yixue yu linchuang mechanical ventilation|pulmonary infection|pyruvate kinase m2(pkm2)|galectin-3(gal-3)|citrullinated histone h3(cith3)|prognosis |
| title | Elevated levels of serum PKM2, Gal-3 and CitH3 could predict pulmonary infection complicated by mechanical ventilation |
| title_full | Elevated levels of serum PKM2, Gal-3 and CitH3 could predict pulmonary infection complicated by mechanical ventilation |
| title_fullStr | Elevated levels of serum PKM2, Gal-3 and CitH3 could predict pulmonary infection complicated by mechanical ventilation |
| title_full_unstemmed | Elevated levels of serum PKM2, Gal-3 and CitH3 could predict pulmonary infection complicated by mechanical ventilation |
| title_short | Elevated levels of serum PKM2, Gal-3 and CitH3 could predict pulmonary infection complicated by mechanical ventilation |
| title_sort | elevated levels of serum pkm2 gal 3 and cith3 could predict pulmonary infection complicated by mechanical ventilation |
| topic | mechanical ventilation|pulmonary infection|pyruvate kinase m2(pkm2)|galectin-3(gal-3)|citrullinated histone h3(cith3)|prognosis |
| url | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-1-86.pdf |
| work_keys_str_mv | AT huanghangdonglidanyuzhuxiaofeng elevatedlevelsofserumpkm2gal3andcith3couldpredictpulmonaryinfectioncomplicatedbymechanicalventilation |