Endothelial-to-mesenchymal transition in the tumor microenvironment: Roles of transforming growth factor-β and matrix metalloproteins

Endothelial-to-mesenchymal transition in the tumor microenvironment: Roles of transforming growth factor-β and matrix metalloproteins

Cancer is a leading cause of global morbidity and mortality. Tumor cells grow in a complex microenvironment, comprising immune cells, stromal cells, and vascular cells, collaborating to support tumor growth and facilitate metastasis. Transforming growth factor-beta (TGF-β) is a multipotent factor th...

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Bibliographic Details
Main Authors: Fei Du, Jing Li, Xiaolin Zhong, Zhuo Zhang, Yueshui Zhao
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
EndMT
TME
TGF-β
MMPs
Combination therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402416149X
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