Clinical and neurological specifics of the vertebrogenic lumbosacral radiculopathy course in the patients with RS1143627 polymorphism of the <i>IL-1β</i> gene
Rationale: Vertebrogenic lumbosacral radiculopathy (VLSRP) is a consequence of exposure to physical exertion, back injuries, and smoking. Genetic polymorphism of the cytokine IL-1β contributes to the progression of VLSRP due to its increased production in certain genetic variants. Aim: To establi...
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MONIKI
2024-12-01
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| Series: | Alʹmanah Kliničeskoj Mediciny |
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| Online Access: | https://almclinmed.ru/jour/article/viewFile/17312/1697 |
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| author | Elena A. Statinova Natalya V. Fominova Maria S. Kishenya |
| author_facet | Elena A. Statinova Natalya V. Fominova Maria S. Kishenya |
| author_sort | Elena A. Statinova |
| collection | DOAJ |
| description | Rationale: Vertebrogenic lumbosacral radiculopathy (VLSRP) is a consequence of exposure to physical exertion, back injuries, and smoking. Genetic polymorphism of the cytokine IL-1β contributes to the progression of VLSRP due to its increased production in certain genetic variants.
Aim: To establish an association between the rs1143627 polymorphism of the IL-1β gene with VLSRP, as well as with clinical and neurological specifics of VLSRP during its treatment.
Methods: The study involved 121 patients with VLSRP aged 22 to 66 years (median, 41 [35; 49] years; men, 110 (90.91%)), treated in the in-patient Department of Neurology from January 2023 to February 2024, and 100 age- and gender compatible healthy subjects. Based on the results of clinical and neurological assessments, the indices of the Digital Rating Scale, Oswestry and Roland-Morris questionnaires were determined. The rs1143627 polymorphism was identified by real-time polymerase chain reaction (IQ5 amplifier (Bio-Rad, USA)) with the SNP-express (IL-1β-31C/T) test system (Litech, Russia).
Results: VLSRP was associated with the distribution of alleles (χ2 = 3.93; p = 0.049) and genotypes according to the dominant model (χ2 = 4.7; p = 0.032) of the rs1143627 polymorphism of the IL-1β gene. The minor T allele increased the odds ratio for VLSRP (OR 1.51; 95% CI 1.004–2.26) in the dominant model; the sum of CC + CT genotypes was also associated with increased VPSRP odds ratio (OR 1.814; 95% CI 1.056–3.115). The DRS scores under treatment showed the significant predominance of pain in the T (CT + TT) allele carriers (p 0.001). As assessed by the Oswestry and Roland-Morris questionnaires, the minor T allele in CT + TT genotypes demonstrated prevailing everyday life activities and less effective results after a treatment course (p 0.001). In the study subjects of ≤ 41 years of age, the multiplicative model showed a higher risk of VLSRP with the minor T allele by 1.8-fold (OR 1.80; 95% CI 1.02–3.19). In the dominant model, the sum of genotypes with the minor T allele (CT + TT) was associated with a 2.23-fold higher risk of VLSRP (OR 2.23; 95% CI 1.05–4.72).
Conclusions: We were able to find the association between the rs1143627 polymorphism of the IL-1β gene with VLSRP, with a higher risk of the disease in the patients of ≤ 41 years of age, higher DRS, Oswestry, and Roland-Morris questionnaire scores, which was related to the presence of a minor T allele and CT + TT genotypes. |
| format | Article |
| id | doaj-art-cb3b8fd3e4794c08988fb977d6670239 |
| institution | Kabale University |
| issn | 2072-0505 2587-9294 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | MONIKI |
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| series | Alʹmanah Kliničeskoj Mediciny |
| spelling | doaj-art-cb3b8fd3e4794c08988fb977d66702392025-01-15T13:59:41ZrusMONIKIAlʹmanah Kliničeskoj Mediciny2072-05052587-92942024-12-0152630731410.18786/2072-0505-2024-52-0311014Clinical and neurological specifics of the vertebrogenic lumbosacral radiculopathy course in the patients with RS1143627 polymorphism of the <i>IL-1β</i> geneElena A. Statinova0https://orcid.org/0000-0002-7477-8857Natalya V. Fominova1Maria S. Kishenya2https://orcid.org/0009-0007-7987-4091M. Gorky Donetsk State Medical UniversityM. Gorky Donetsk State Medical UniversityM. Gorky Donetsk State Medical UniversityRationale: Vertebrogenic lumbosacral radiculopathy (VLSRP) is a consequence of exposure to physical exertion, back injuries, and smoking. Genetic polymorphism of the cytokine IL-1β contributes to the progression of VLSRP due to its increased production in certain genetic variants. Aim: To establish an association between the rs1143627 polymorphism of the IL-1β gene with VLSRP, as well as with clinical and neurological specifics of VLSRP during its treatment. Methods: The study involved 121 patients with VLSRP aged 22 to 66 years (median, 41 [35; 49] years; men, 110 (90.91%)), treated in the in-patient Department of Neurology from January 2023 to February 2024, and 100 age- and gender compatible healthy subjects. Based on the results of clinical and neurological assessments, the indices of the Digital Rating Scale, Oswestry and Roland-Morris questionnaires were determined. The rs1143627 polymorphism was identified by real-time polymerase chain reaction (IQ5 amplifier (Bio-Rad, USA)) with the SNP-express (IL-1β-31C/T) test system (Litech, Russia). Results: VLSRP was associated with the distribution of alleles (χ2 = 3.93; p = 0.049) and genotypes according to the dominant model (χ2 = 4.7; p = 0.032) of the rs1143627 polymorphism of the IL-1β gene. The minor T allele increased the odds ratio for VLSRP (OR 1.51; 95% CI 1.004–2.26) in the dominant model; the sum of CC + CT genotypes was also associated with increased VPSRP odds ratio (OR 1.814; 95% CI 1.056–3.115). The DRS scores under treatment showed the significant predominance of pain in the T (CT + TT) allele carriers (p 0.001). As assessed by the Oswestry and Roland-Morris questionnaires, the minor T allele in CT + TT genotypes demonstrated prevailing everyday life activities and less effective results after a treatment course (p 0.001). In the study subjects of ≤ 41 years of age, the multiplicative model showed a higher risk of VLSRP with the minor T allele by 1.8-fold (OR 1.80; 95% CI 1.02–3.19). In the dominant model, the sum of genotypes with the minor T allele (CT + TT) was associated with a 2.23-fold higher risk of VLSRP (OR 2.23; 95% CI 1.05–4.72). Conclusions: We were able to find the association between the rs1143627 polymorphism of the IL-1β gene with VLSRP, with a higher risk of the disease in the patients of ≤ 41 years of age, higher DRS, Oswestry, and Roland-Morris questionnaire scores, which was related to the presence of a minor T allele and CT + TT genotypes.https://almclinmed.ru/jour/article/viewFile/17312/1697vertebrogenic lumbosacral radiculopathydigital rating scaleoswestry questionnairers1143627 polymorphismil-1β gene |
| spellingShingle | Elena A. Statinova Natalya V. Fominova Maria S. Kishenya Clinical and neurological specifics of the vertebrogenic lumbosacral radiculopathy course in the patients with RS1143627 polymorphism of the <i>IL-1β</i> gene Alʹmanah Kliničeskoj Mediciny vertebrogenic lumbosacral radiculopathy digital rating scale oswestry questionnaire rs1143627 polymorphism il-1β gene |
| title | Clinical and neurological specifics of the vertebrogenic lumbosacral radiculopathy course in the patients with RS1143627 polymorphism of the <i>IL-1β</i> gene |
| title_full | Clinical and neurological specifics of the vertebrogenic lumbosacral radiculopathy course in the patients with RS1143627 polymorphism of the <i>IL-1β</i> gene |
| title_fullStr | Clinical and neurological specifics of the vertebrogenic lumbosacral radiculopathy course in the patients with RS1143627 polymorphism of the <i>IL-1β</i> gene |
| title_full_unstemmed | Clinical and neurological specifics of the vertebrogenic lumbosacral radiculopathy course in the patients with RS1143627 polymorphism of the <i>IL-1β</i> gene |
| title_short | Clinical and neurological specifics of the vertebrogenic lumbosacral radiculopathy course in the patients with RS1143627 polymorphism of the <i>IL-1β</i> gene |
| title_sort | clinical and neurological specifics of the vertebrogenic lumbosacral radiculopathy course in the patients with rs1143627 polymorphism of the i il 1β i gene |
| topic | vertebrogenic lumbosacral radiculopathy digital rating scale oswestry questionnaire rs1143627 polymorphism il-1β gene |
| url | https://almclinmed.ru/jour/article/viewFile/17312/1697 |
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