Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic metabolic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1494560/full |
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| author | Yu-Hong Fan Siyao Zhang Ye Wang Hongni Wang Hongliang Li Hongliang Li Hongliang Li Lan Bai |
| author_facet | Yu-Hong Fan Siyao Zhang Ye Wang Hongni Wang Hongliang Li Hongliang Li Hongliang Li Lan Bai |
| author_sort | Yu-Hong Fan |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic metabolic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, and potentially liver cancer. This disease is closely associated with metabolic disorders driven by overnutrition, with key pathological processes including lipid dysregulation, impaired lipid autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and local inflammation. While hepatic lipid metabolism in NAFLD is well-documented, further research into inter-organ communication mechanisms is crucial for a deeper understanding of NAFLD progression. This review delves into intrahepatic networks and tissue-specific signaling mediators involved in NAFLD pathogenesis, emphasizing their impact on distal organs. |
| format | Article |
| id | doaj-art-cb33a5ade515455997a4c203027e2b99 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-cb33a5ade515455997a4c203027e2b992025-01-09T05:10:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14945601494560Inter-organ metabolic interaction networks in non-alcoholic fatty liver diseaseYu-Hong Fan0Siyao Zhang1Ye Wang2Hongni Wang3Hongliang Li4Hongliang Li5Hongliang Li6Lan Bai7State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou, ChinaState Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou, ChinaState Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou, ChinaState Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou, ChinaState Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Ganzhou, ChinaDepartment of Cardiology, Renmin Hospital, Wuhan University, Wuhan, ChinaMedical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, ChinaState Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaNon-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic metabolic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, and potentially liver cancer. This disease is closely associated with metabolic disorders driven by overnutrition, with key pathological processes including lipid dysregulation, impaired lipid autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and local inflammation. While hepatic lipid metabolism in NAFLD is well-documented, further research into inter-organ communication mechanisms is crucial for a deeper understanding of NAFLD progression. This review delves into intrahepatic networks and tissue-specific signaling mediators involved in NAFLD pathogenesis, emphasizing their impact on distal organs.https://www.frontiersin.org/articles/10.3389/fendo.2024.1494560/fullnon-alcoholic fatty liver diseaseInter-organ crosstalkfatty acid synthesismitochondrial homeostasisendoplasmic reticulum (ER) stress |
| spellingShingle | Yu-Hong Fan Siyao Zhang Ye Wang Hongni Wang Hongliang Li Hongliang Li Hongliang Li Lan Bai Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease Frontiers in Endocrinology non-alcoholic fatty liver disease Inter-organ crosstalk fatty acid synthesis mitochondrial homeostasis endoplasmic reticulum (ER) stress |
| title | Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease |
| title_full | Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease |
| title_fullStr | Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease |
| title_full_unstemmed | Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease |
| title_short | Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease |
| title_sort | inter organ metabolic interaction networks in non alcoholic fatty liver disease |
| topic | non-alcoholic fatty liver disease Inter-organ crosstalk fatty acid synthesis mitochondrial homeostasis endoplasmic reticulum (ER) stress |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1494560/full |
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