Cord Blood Bilirubin as a Predictor of Neonatal Hyperbilirubinemia
Introduction: In the 1st week of life, hyperbilirubinemia is the most common clinical condition in newborns that has to be evaluated and treated. It is also a prominent cause of readmission to the hospital. Some newborns experience noticeable, potentially dangerous bilirubin levels, which can direct...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Acta Medica International |
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| Online Access: | https://journals.lww.com/10.4103/amit.amit_46_24 |
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| author | Saman Beg Uzma Firdaus Syed Manazir Ali |
| author_facet | Saman Beg Uzma Firdaus Syed Manazir Ali |
| author_sort | Saman Beg |
| collection | DOAJ |
| description | Introduction:
In the 1st week of life, hyperbilirubinemia is the most common clinical condition in newborns that has to be evaluated and treated. It is also a prominent cause of readmission to the hospital. Some newborns experience noticeable, potentially dangerous bilirubin levels, which can directly increase the risk of severe brain damage, despite it being a benign, postnatal, transitory phenomenon. The current investigation looked at the relationship between cord blood bilirubin levels and the predictability of pathological jaundice.
Materials and Methods:
Cord blood bilirubin was estimated at birth. Bilirubin estimation was done at 48 h, 72 h, and 5–7 days of life using a trans-bilirubinometer. The study was approved by the Institutional Ethical Committee.
Results:
Significant hyperbilirubinemia was found in 3.7% of the neonates. A statistically significant correlation was found between cord blood bilirubin and the development of significant hyperbilirubinemia at 48 h of life. Gender, gestational age, birth weight, and use of Oxytocin have no correlation with cord bilirubin or the subsequent development of jaundice. A cord blood value of >2 mg/dL has a high negative predictive value (98%), sensitivity (83%), specificity (41%), and positive predictive value (5.3%) in predicting the future development of future pathological jaundice.
Conclusions:
A high negative predictive value in our study suggests that healthy term babies with cord bilirubin ≤2 mg/dL can be discharged early with assurance to parents. Babies with cord blood bilirubin >2 mg/dL should be followed more frequently. |
| format | Article |
| id | doaj-art-cb20b45e22294b97aa485abdb10f2289 |
| institution | Kabale University |
| issn | 2349-0578 2349-0896 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Acta Medica International |
| spelling | doaj-art-cb20b45e22294b97aa485abdb10f22892025-01-06T14:27:37ZengWolters Kluwer Medknow PublicationsActa Medica International2349-05782349-08962024-12-0111320921210.4103/amit.amit_46_24Cord Blood Bilirubin as a Predictor of Neonatal HyperbilirubinemiaSaman BegUzma FirdausSyed Manazir AliIntroduction: In the 1st week of life, hyperbilirubinemia is the most common clinical condition in newborns that has to be evaluated and treated. It is also a prominent cause of readmission to the hospital. Some newborns experience noticeable, potentially dangerous bilirubin levels, which can directly increase the risk of severe brain damage, despite it being a benign, postnatal, transitory phenomenon. The current investigation looked at the relationship between cord blood bilirubin levels and the predictability of pathological jaundice. Materials and Methods: Cord blood bilirubin was estimated at birth. Bilirubin estimation was done at 48 h, 72 h, and 5–7 days of life using a trans-bilirubinometer. The study was approved by the Institutional Ethical Committee. Results: Significant hyperbilirubinemia was found in 3.7% of the neonates. A statistically significant correlation was found between cord blood bilirubin and the development of significant hyperbilirubinemia at 48 h of life. Gender, gestational age, birth weight, and use of Oxytocin have no correlation with cord bilirubin or the subsequent development of jaundice. A cord blood value of >2 mg/dL has a high negative predictive value (98%), sensitivity (83%), specificity (41%), and positive predictive value (5.3%) in predicting the future development of future pathological jaundice. Conclusions: A high negative predictive value in our study suggests that healthy term babies with cord bilirubin ≤2 mg/dL can be discharged early with assurance to parents. Babies with cord blood bilirubin >2 mg/dL should be followed more frequently.https://journals.lww.com/10.4103/amit.amit_46_24cord blood bilirubinhigh negative predictive valuehyperbilirubinemiatrans-bilirubinometer |
| spellingShingle | Saman Beg Uzma Firdaus Syed Manazir Ali Cord Blood Bilirubin as a Predictor of Neonatal Hyperbilirubinemia Acta Medica International cord blood bilirubin high negative predictive value hyperbilirubinemia trans-bilirubinometer |
| title | Cord Blood Bilirubin as a Predictor of Neonatal Hyperbilirubinemia |
| title_full | Cord Blood Bilirubin as a Predictor of Neonatal Hyperbilirubinemia |
| title_fullStr | Cord Blood Bilirubin as a Predictor of Neonatal Hyperbilirubinemia |
| title_full_unstemmed | Cord Blood Bilirubin as a Predictor of Neonatal Hyperbilirubinemia |
| title_short | Cord Blood Bilirubin as a Predictor of Neonatal Hyperbilirubinemia |
| title_sort | cord blood bilirubin as a predictor of neonatal hyperbilirubinemia |
| topic | cord blood bilirubin high negative predictive value hyperbilirubinemia trans-bilirubinometer |
| url | https://journals.lww.com/10.4103/amit.amit_46_24 |
| work_keys_str_mv | AT samanbeg cordbloodbilirubinasapredictorofneonatalhyperbilirubinemia AT uzmafirdaus cordbloodbilirubinasapredictorofneonatalhyperbilirubinemia AT syedmanazirali cordbloodbilirubinasapredictorofneonatalhyperbilirubinemia |