Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenance

Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenance

Abstract Preserving a large number of essential yet highly unstable ribosomal DNA (rDNA) repeats is critical for the germline to perpetuate the genome through generations. Spontaneous rDNA loss must be countered by rDNA copy number (CN) expansion. Germline rDNA CN expansion is best understood in Dro...

Full description

Saved in:
Bibliographic Details
Main Authors: Jonathan O. Nelson, Alyssa Slicko, Amelie A. Raz, Yukiko M. Yamashita
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55725-6
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items