Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotypeResearch in context

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotypeResearch in context

Summary: Background: Nearly all transmitted/founder (T/F) HIV-1 are CCR5 (R5)-tropic. While previous evidence suggested that CXCR4 (X4)-tropic HIV-1 are transmissible, virus detection and characterization were not at the earliest stages of acute infection. Methods: We identified an X4-tropic T/F HI...

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Main Authors: Manukumar Honnayakanahalli Marichannegowda, Saini Setua, Meera Bose, Eric Sanders-Buell, David King, Michelle Zemil, Lindsay Wieczorek, Felisa Diaz-Mendez, Nicolas Chomont, Rasmi Thomas, Leilani Francisco, Leigh Anne Eller, Victoria R. Polonis, Sodsai Tovanabutra, Alonso Heredia, Yutaka Tagaya, Nelson L. Michael, Merlin L. Robb, Hongshuo Song
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:EBioMedicine
Subjects:
HIV-1
CXCR4
Mucosal transmission
CD4 subset
Pathogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424004468
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