SIRT2 Inhibition by AGK2 Promotes Perinuclear Cytoskeletal Organisation and Reduces Invasiveness of MDA-MB-231 Triple-Negative Breast Cancer Cells in Confined In Vitro Models

SIRT2 Inhibition by AGK2 Promotes Perinuclear Cytoskeletal Organisation and Reduces Invasiveness of MDA-MB-231 Triple-Negative Breast Cancer Cells in Confined In Vitro Models

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterised by the absence of targetable hormone receptors and increased metastatic rates. As nuclear softening strongly contributes to TNBC’s enhanced metastatic capacity, increasing the nuclear stiffness of TNBC ce...

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Bibliographic Details
Main Authors: Emily Jessop, Natalie Young, Beatriz Garcia-Del-Valle, Jack T. Crusher, Boguslaw Obara, Iakowos Karakesisoglou
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
AGK2
lamin
LINC complex
microtubules
nesprins
nuclear mechanics
Online Access:https://www.mdpi.com/2073-4409/13/23/2023
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