Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep
<b>Aim:</b> The aim of this study is to determine the effects of diclofenac sodium and meloxicam administrations on coagulation parameters in sheep.<p> <b>Materials and Methods: </b>This study was carried out on 12 Akkaraman healthy sheep and they were divided into two...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1232 |
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| author | Ramazan Yıldız Orhan Çorum Orkun Atik Duygu Durna Çorum Merve İder Mahmut Ok Kamil Üney |
| author_facet | Ramazan Yıldız Orhan Çorum Orkun Atik Duygu Durna Çorum Merve İder Mahmut Ok Kamil Üney |
| author_sort | Ramazan Yıldız |
| collection | DOAJ |
| description | <b>Aim:</b> The aim of this study is to determine the effects of diclofenac
sodium and meloxicam administrations on coagulation
parameters in sheep.<p>
<b>Materials and Methods: </b>This study was carried out on 12 Akkaraman
healthy sheep and they were divided into two groups
as the diclofenac sodium group (DS) and meloxicam group (MS),
equally. In the DS group, diclofenac sodium (2.5 mg / kg) and
in MS group, meloxicam (0.5 mg / kg) was administered intramuscularly
once daily for 3 days. Blood samples were taken
before the drug administration (0 h) and at 72 hours following
administration. The plasma fibrinogen, activated partial thromboplastin
time (APTT), prothrombin time (PT), D-dimer and
platelet count (PLT) levels were determined at 0 and 72 hours.<p>
<b>Results:</b> During the study, there was no difference in the clinical
examination findings of the groups. No statistically differences
(P > 0.05) were found in fibrinogen, APTT, PT, D-dimer, and PLT
parameters in the DS and MS groups at 0 and 72 hours.<p>
<b>Conclusion:</b> It may be stated that administrations of diclofenac
sodium and meloxicam for 3 days in sheep may not cause any
change in the coagulation parameters. |
| format | Article |
| id | doaj-art-caf87fb03a574861b49e72ff2a6eb9e9 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-caf87fb03a574861b49e72ff2a6eb9e92025-01-02T22:36:19ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19533442902931232Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheepRamazan Yıldız0Orhan ÇorumOrkun Atik1Duygu Durna Çorum2Merve İder3Mahmut Ok4Kamil Üney5Mehmet Akif Ersoy Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Burdur, TürkiyeAfyon Kocatepe Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Afyonkarahisar, TürkiyeKastamonu Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Kastamonu, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, Türkiye<b>Aim:</b> The aim of this study is to determine the effects of diclofenac sodium and meloxicam administrations on coagulation parameters in sheep.<p> <b>Materials and Methods: </b>This study was carried out on 12 Akkaraman healthy sheep and they were divided into two groups as the diclofenac sodium group (DS) and meloxicam group (MS), equally. In the DS group, diclofenac sodium (2.5 mg / kg) and in MS group, meloxicam (0.5 mg / kg) was administered intramuscularly once daily for 3 days. Blood samples were taken before the drug administration (0 h) and at 72 hours following administration. The plasma fibrinogen, activated partial thromboplastin time (APTT), prothrombin time (PT), D-dimer and platelet count (PLT) levels were determined at 0 and 72 hours.<p> <b>Results:</b> During the study, there was no difference in the clinical examination findings of the groups. No statistically differences (P > 0.05) were found in fibrinogen, APTT, PT, D-dimer, and PLT parameters in the DS and MS groups at 0 and 72 hours.<p> <b>Conclusion:</b> It may be stated that administrations of diclofenac sodium and meloxicam for 3 days in sheep may not cause any change in the coagulation parameters.http://eurasianjvetsci.org/pdf.php3?id=1232sheepdiclofenac sodiummeloxicamcoagulation |
| spellingShingle | Ramazan Yıldız Orhan Çorum Orkun Atik Duygu Durna Çorum Merve İder Mahmut Ok Kamil Üney Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep Eurasian Journal of Veterinary Sciences sheep diclofenac sodium meloxicam coagulation |
| title | Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep |
| title_full | Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep |
| title_fullStr | Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep |
| title_full_unstemmed | Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep |
| title_short | Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep |
| title_sort | effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep |
| topic | sheep diclofenac sodium meloxicam coagulation |
| url | http://eurasianjvetsci.org/pdf.php3?id=1232 |
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