Effect of repeated administration of diclofenac sodium and meloxicam on coagulation parameters in sheep
<b>Aim:</b> The aim of this study is to determine the effects of diclofenac sodium and meloxicam administrations on coagulation parameters in sheep.<p> <b>Materials and Methods: </b>This study was carried out on 12 Akkaraman healthy sheep and they were divided into two...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1232 |
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| Summary: | <b>Aim:</b> The aim of this study is to determine the effects of diclofenac
sodium and meloxicam administrations on coagulation
parameters in sheep.<p>
<b>Materials and Methods: </b>This study was carried out on 12 Akkaraman
healthy sheep and they were divided into two groups
as the diclofenac sodium group (DS) and meloxicam group (MS),
equally. In the DS group, diclofenac sodium (2.5 mg / kg) and
in MS group, meloxicam (0.5 mg / kg) was administered intramuscularly
once daily for 3 days. Blood samples were taken
before the drug administration (0 h) and at 72 hours following
administration. The plasma fibrinogen, activated partial thromboplastin
time (APTT), prothrombin time (PT), D-dimer and
platelet count (PLT) levels were determined at 0 and 72 hours.<p>
<b>Results:</b> During the study, there was no difference in the clinical
examination findings of the groups. No statistically differences
(P > 0.05) were found in fibrinogen, APTT, PT, D-dimer, and PLT
parameters in the DS and MS groups at 0 and 72 hours.<p>
<b>Conclusion:</b> It may be stated that administrations of diclofenac
sodium and meloxicam for 3 days in sheep may not cause any
change in the coagulation parameters. |
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| ISSN: | 1309-6958 2146-1953 |