Comparative assessment of diagnostic accuracy: Helicobacter pylori stool antigen test versus rapid urease test in adult patients with upper gastrointestinal symptoms
Background and aim Helicobacter pylori (H. pylori) is the leading cause of human stomach infections. Accurate diagnosis is ucial for the effective management of H. pylori, leading to the eation of numerous diagnostic techniques, including both invasive and noninvasive methods. Methods This study tho...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Al-Azhar Assiut Medical Journal |
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| Online Access: | https://journals.lww.com/10.4103/azmj.azmj_34_24 |
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| author | Mohamed Fakhry Khaled Abdelazeem Mona M. Abdelmeguid Mahmoud A. Abdelmaksoud Emad Abdelrazzak Omran M. Abdelmola Safwat Salama Waleed S. EL-Nasser Maha Mohamed Mohamed A. Younes Amro M. Hassan |
| author_facet | Mohamed Fakhry Khaled Abdelazeem Mona M. Abdelmeguid Mahmoud A. Abdelmaksoud Emad Abdelrazzak Omran M. Abdelmola Safwat Salama Waleed S. EL-Nasser Maha Mohamed Mohamed A. Younes Amro M. Hassan |
| author_sort | Mohamed Fakhry |
| collection | DOAJ |
| description | Background and aim
Helicobacter pylori (H. pylori) is the leading cause of human stomach infections. Accurate diagnosis is ucial for the effective management of H. pylori, leading to the eation of numerous diagnostic techniques, including both invasive and noninvasive methods.
Methods
This study thoroughly examines the diagnostic accuracy of the H. pylori Stool Antigen (HpSA) test in comparison to the rapid urease test (RUT). Background and aim HpSA test, known for being non-invasive, cost-effective, and quick, is contrasted with the fast but invasive RUT. Conducted on 100 adult patients from June to December 2022, the study utilized a comprehensive diagnostic approach, including medical history evaluations, physical exams, abdominal ultrasounds, laboratory tests, and careful stool sample collection. Additionally, all participants underwent RUT, stool antigen tests, and histopathology examinations.
Results
The findings revealed that the HpSA test identified more positive H. pylori cases (73) than the RUT (59) (P<0.01). Although RUT results closely matched histopathology outcomes, both RUT and histopathology showed greater accuracy than HpSA. Furthermore, RUT demonstrated higher sensitivity (98.2%) and accuracy (98.3%) compared with HpSA, while specificity was similar for both tests.
Conclusion
The HpSA test is a straightforward and noninvasive diagnostic method that is easy to use in laboratory settings. On the other hand, the RUT is known for its high accuracy and sensitivity. Together, these characteristics make the HpSA test a valuable alternative for diagnostic purposes. |
| format | Article |
| id | doaj-art-cae9d5f807fb4cedb534f63920c9e848 |
| institution | Kabale University |
| issn | 1687-1693 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Al-Azhar Assiut Medical Journal |
| spelling | doaj-art-cae9d5f807fb4cedb534f63920c9e8482025-01-17T15:57:39ZengWolters Kluwer Medknow PublicationsAl-Azhar Assiut Medical Journal1687-16932024-04-0122211011710.4103/azmj.azmj_34_24Comparative assessment of diagnostic accuracy: Helicobacter pylori stool antigen test versus rapid urease test in adult patients with upper gastrointestinal symptomsMohamed FakhryKhaled AbdelazeemMona M. AbdelmeguidMahmoud A. AbdelmaksoudEmad AbdelrazzakOmran M. AbdelmolaSafwat SalamaWaleed S. EL-NasserMaha MohamedMohamed A. YounesAmro M. HassanBackground and aim Helicobacter pylori (H. pylori) is the leading cause of human stomach infections. Accurate diagnosis is ucial for the effective management of H. pylori, leading to the eation of numerous diagnostic techniques, including both invasive and noninvasive methods. Methods This study thoroughly examines the diagnostic accuracy of the H. pylori Stool Antigen (HpSA) test in comparison to the rapid urease test (RUT). Background and aim HpSA test, known for being non-invasive, cost-effective, and quick, is contrasted with the fast but invasive RUT. Conducted on 100 adult patients from June to December 2022, the study utilized a comprehensive diagnostic approach, including medical history evaluations, physical exams, abdominal ultrasounds, laboratory tests, and careful stool sample collection. Additionally, all participants underwent RUT, stool antigen tests, and histopathology examinations. Results The findings revealed that the HpSA test identified more positive H. pylori cases (73) than the RUT (59) (P<0.01). Although RUT results closely matched histopathology outcomes, both RUT and histopathology showed greater accuracy than HpSA. Furthermore, RUT demonstrated higher sensitivity (98.2%) and accuracy (98.3%) compared with HpSA, while specificity was similar for both tests. Conclusion The HpSA test is a straightforward and noninvasive diagnostic method that is easy to use in laboratory settings. On the other hand, the RUT is known for its high accuracy and sensitivity. Together, these characteristics make the HpSA test a valuable alternative for diagnostic purposes.https://journals.lww.com/10.4103/azmj.azmj_34_24diagnostic accuracyhelicobacter pylorirapid stool antigen test |
| spellingShingle | Mohamed Fakhry Khaled Abdelazeem Mona M. Abdelmeguid Mahmoud A. Abdelmaksoud Emad Abdelrazzak Omran M. Abdelmola Safwat Salama Waleed S. EL-Nasser Maha Mohamed Mohamed A. Younes Amro M. Hassan Comparative assessment of diagnostic accuracy: Helicobacter pylori stool antigen test versus rapid urease test in adult patients with upper gastrointestinal symptoms Al-Azhar Assiut Medical Journal diagnostic accuracy helicobacter pylori rapid stool antigen test |
| title | Comparative assessment of diagnostic accuracy: Helicobacter pylori stool antigen test versus rapid urease test in adult patients with upper gastrointestinal symptoms |
| title_full | Comparative assessment of diagnostic accuracy: Helicobacter pylori stool antigen test versus rapid urease test in adult patients with upper gastrointestinal symptoms |
| title_fullStr | Comparative assessment of diagnostic accuracy: Helicobacter pylori stool antigen test versus rapid urease test in adult patients with upper gastrointestinal symptoms |
| title_full_unstemmed | Comparative assessment of diagnostic accuracy: Helicobacter pylori stool antigen test versus rapid urease test in adult patients with upper gastrointestinal symptoms |
| title_short | Comparative assessment of diagnostic accuracy: Helicobacter pylori stool antigen test versus rapid urease test in adult patients with upper gastrointestinal symptoms |
| title_sort | comparative assessment of diagnostic accuracy helicobacter pylori stool antigen test versus rapid urease test in adult patients with upper gastrointestinal symptoms |
| topic | diagnostic accuracy helicobacter pylori rapid stool antigen test |
| url | https://journals.lww.com/10.4103/azmj.azmj_34_24 |
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