Benzimidazole resistance-associated mutations improve the in silico dimerization of hookworm tubulin: An additional resistance mechanism

Benzimidazole resistance-associated mutations improve the in silico dimerization of hookworm tubulin: An additional resistance mechanism

Background and Aim: Mutations in the β-tubulin genes of helminths confer benzimidazole (BZ) resistance by reducing the drug’s binding efficiency to the expressed protein. However, the effects of these resistance-associated mutations on tubulin dimer formation in soil-transmitted helminths remain unk...

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Bibliographic Details
Main Authors: Jan Clyden B. Tenorio, Muhammad Fikri Heikal, Alok Kafle, Prasert Saichua, Sutas Suttiprapa
Format: Article
Language:English
Published: Veterinary World 2024-12-01
Series:Veterinary World
Subjects:
ancylostoma
anthelmintic resistance
microtubules
soil-transmitted helminths
Online Access:https://www.veterinaryworld.org/Vol.17/December-2024/5.pdf
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