Detection of human papillomavirus infection in oral mucosal diseasesWhy Is This Important?
Background: Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers but only a small proportion of oral cavity cancers. This study aimed to investigate the presence of HPV DNA in oral diseases to understand better the possible correlation between oral lesions and HPV...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | JADA Foundational Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772414X2400001X |
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| author | Paolo Junior Fantozzi, DDS Umberto Romeo, DDS Gianluca Tenore, DDS, PhD Gaspare Palaia, DDS, PhD Chiara Ciolfi, DDS Alessandra Pierangeli, PhD Cira Rosaria Tiziana Di Gioia, MD, PhD Alessandro Villa, DDS, PhD, MPH |
| author_facet | Paolo Junior Fantozzi, DDS Umberto Romeo, DDS Gianluca Tenore, DDS, PhD Gaspare Palaia, DDS, PhD Chiara Ciolfi, DDS Alessandra Pierangeli, PhD Cira Rosaria Tiziana Di Gioia, MD, PhD Alessandro Villa, DDS, PhD, MPH |
| author_sort | Paolo Junior Fantozzi, DDS |
| collection | DOAJ |
| description | Background: Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers but only a small proportion of oral cavity cancers. This study aimed to investigate the presence of HPV DNA in oral diseases to understand better the possible correlation between oral lesions and HPV infections. Methods: This was a cross-sectional study of 99 adult patients seen for the evaluation of oral diseases. All patients received an oral biopsy and histopathologic examination and a brush biopsy for HPV-DNA detection and genotyping by real-time polymerase chain reaction. Immunohistochemistry was used to assess p16INK4a expression. Results: HPV was identified in 15 of 99 (15.2%) patients (males, 66.6%). Patients with oral leukoplakia (OL) (46.6%), followed by patients with oral lichen planus (OLP) (33.3%) had the highest rate of HPV infection, with a predilection for the buccal mucosa (17.5%). Most patients with high-risk HPV infections had OLP (4/10, 40.0%), whereas most of the patients with low-risk HPV infections had nonreactive epithelial hyperkeratosis (3/6, 50.0%). Among all benign lesions, 19.0% were positive for any HPV infection. One patient with OL showing mild epithelial dysplasia had a positive p16INK4a expression. Conclusions: The highest rate of HPV infection was in male patients, patients with OL and OLP, and conditions affecting the buccal mucosa. Larger studies are needed to elucidate the role of HPV in the development of these conditions. |
| format | Article |
| id | doaj-art-cad8a231b1d44ea9b08f9ee7d343c595 |
| institution | Kabale University |
| issn | 2772-414X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JADA Foundational Science |
| spelling | doaj-art-cad8a231b1d44ea9b08f9ee7d343c5952025-01-10T04:38:36ZengElsevierJADA Foundational Science2772-414X2024-01-013100031Detection of human papillomavirus infection in oral mucosal diseasesWhy Is This Important?Paolo Junior Fantozzi, DDS0Umberto Romeo, DDS1Gianluca Tenore, DDS, PhD2Gaspare Palaia, DDS, PhD3Chiara Ciolfi, DDS4Alessandra Pierangeli, PhD5Cira Rosaria Tiziana Di Gioia, MD, PhD6Alessandro Villa, DDS, PhD, MPH7Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyLaboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological, and Anatomic Pathological Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Orofacial Sciences, University of California San Francisco, San Francisco, CA; Oral Medicine, Oral Oncology and Dentistry, Miami Cancer Institute, Baptist Health South Florida, The Herbert Wertheim College of Medicine, Florida International University, Miami, FL; Address correspondence to Dr Villa.Background: Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers but only a small proportion of oral cavity cancers. This study aimed to investigate the presence of HPV DNA in oral diseases to understand better the possible correlation between oral lesions and HPV infections. Methods: This was a cross-sectional study of 99 adult patients seen for the evaluation of oral diseases. All patients received an oral biopsy and histopathologic examination and a brush biopsy for HPV-DNA detection and genotyping by real-time polymerase chain reaction. Immunohistochemistry was used to assess p16INK4a expression. Results: HPV was identified in 15 of 99 (15.2%) patients (males, 66.6%). Patients with oral leukoplakia (OL) (46.6%), followed by patients with oral lichen planus (OLP) (33.3%) had the highest rate of HPV infection, with a predilection for the buccal mucosa (17.5%). Most patients with high-risk HPV infections had OLP (4/10, 40.0%), whereas most of the patients with low-risk HPV infections had nonreactive epithelial hyperkeratosis (3/6, 50.0%). Among all benign lesions, 19.0% were positive for any HPV infection. One patient with OL showing mild epithelial dysplasia had a positive p16INK4a expression. Conclusions: The highest rate of HPV infection was in male patients, patients with OL and OLP, and conditions affecting the buccal mucosa. Larger studies are needed to elucidate the role of HPV in the development of these conditions.http://www.sciencedirect.com/science/article/pii/S2772414X2400001XOral medicineoral HPVHuman papillomavirusoral leukoplakiaoral canceroral infections |
| spellingShingle | Paolo Junior Fantozzi, DDS Umberto Romeo, DDS Gianluca Tenore, DDS, PhD Gaspare Palaia, DDS, PhD Chiara Ciolfi, DDS Alessandra Pierangeli, PhD Cira Rosaria Tiziana Di Gioia, MD, PhD Alessandro Villa, DDS, PhD, MPH Detection of human papillomavirus infection in oral mucosal diseasesWhy Is This Important? JADA Foundational Science Oral medicine oral HPV Human papillomavirus oral leukoplakia oral cancer oral infections |
| title | Detection of human papillomavirus infection in oral mucosal diseasesWhy Is This Important? |
| title_full | Detection of human papillomavirus infection in oral mucosal diseasesWhy Is This Important? |
| title_fullStr | Detection of human papillomavirus infection in oral mucosal diseasesWhy Is This Important? |
| title_full_unstemmed | Detection of human papillomavirus infection in oral mucosal diseasesWhy Is This Important? |
| title_short | Detection of human papillomavirus infection in oral mucosal diseasesWhy Is This Important? |
| title_sort | detection of human papillomavirus infection in oral mucosal diseaseswhy is this important |
| topic | Oral medicine oral HPV Human papillomavirus oral leukoplakia oral cancer oral infections |
| url | http://www.sciencedirect.com/science/article/pii/S2772414X2400001X |
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