UQCRC1 downregulation impairs cognitive function in mice via AMPK inactivation

UQCRC1 downregulation impairs cognitive function in mice via AMPK inactivation

Background Ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) is an essential subunit of complex III in the mitochondrial respiratory chain. Although earlier studies have indicated that UQCRC1 downregulation causes cognitive impairment, the underlying mechanisms remain unclear. Methods To inve...

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Bibliographic Details
Main Authors: Jing Zhang, Zuoxi Wu, Zonghong Long, Feng Ceng, Fuhai Bai, Hong Li
Format: Article
Language:English
Published: PeerJ Inc. 2025-08-01
Series:PeerJ
Subjects:
UQCRC1
Cognition
ROS
Hippocampus
Mitochondria
Autophagy
Online Access:https://peerj.com/articles/19873.pdf
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