CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer

CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer

Abstract Elevated squalene epoxidase (SQLE) levels in bladder cancer cells drive abnormal cholesterol accumulation, contributing to malignancy, invasion, and resistance to immunotherapy. Here, we introduce a hollow CuO nanoparticle-based nanotherapeutic, termed CuOTeDsP, which is PEGylated and co-lo...

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Bibliographic Details
Main Authors: Hai Cai, Panpan Xue, Siyuan Liu, Yaxin Ma, Xuemei Zeng, Shuangqian Yan, Ning Xu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Cholesterol metabolism
SQLE
Cuproptosis
Bladder cancer
Immunotherapy
Online Access:https://doi.org/10.1186/s12951-025-03609-2
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