The Effects of Exercise on Antioxidant System and Some Blood Parameters at Experimental Diabetic Rats
The aim of this study is to determine the effects of exercise on antioxidant system (MDA, SOD, GSH) and some blood parameteres (plasma insuline, glucose, ALT, AST) in rats with experimental diabetes induced by streptozotocin (STZ). In the study, 32 adult Wistar Albino rats were divided into 4 equal...
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Selcuk University Press
2021-08-01
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| Series: | Türk Spor ve Egzersiz Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/1728824 |
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| author | Bekir Mehtap Zafer Durgun |
| author_facet | Bekir Mehtap Zafer Durgun |
| author_sort | Bekir Mehtap |
| collection | DOAJ |
| description | The aim of this study is to determine the effects of exercise on antioxidant system (MDA, SOD, GSH) and some blood parameteres (plasma insuline, glucose, ALT, AST) in rats with experimental diabetes induced by streptozotocin (STZ).
In the study, 32 adult Wistar Albino rats were divided into 4 equal groups as control (C), exercise (E), diabetes (D) and diabetes+exercise (DE). Diabetes was induced in D and DE by intraperitoneal injection with a single dose of 60 mg/kg STZ. After the diabetes was induced, swimming exercise was applied to E and DE for 5 days / 30 min a week for 4 weeks. According to the findings obtained; there was a significant decrease in D and DE compared to C. Plasma glucose levels decreased in DE with exercise in the diabetic groups. While ALT levels increased significantly in diabetic groups compared to others, it was found that exercise did not make a difference in diabetics. However, the increase in AST levels was statistically significant only in D. When serum MDA levels were examined, a significant decrease was observed in DE compared to D. While there was a significant decrease in serum SOD levels in the diabetic groups compared to C. The diabetic groups and DE and E were similar to each other. A significant decrease was observed in GSH levels in D. This difference was also detected between diabetic groups.
As a result; in the study it was concluded that regular aerobic exercise improved glycemic control, has a lipid peroxidation-reducing effect and may hava a positive effect on strengthening the antioxidant system in diabetes. |
| format | Article |
| id | doaj-art-caade450949a466899e15f5313ea8127 |
| institution | Kabale University |
| issn | 2147-5652 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Türk Spor ve Egzersiz Dergisi |
| spelling | doaj-art-caade450949a466899e15f5313ea81272025-01-02T22:45:58ZengSelcuk University PressTürk Spor ve Egzersiz Dergisi2147-56522021-08-01232223229154The Effects of Exercise on Antioxidant System and Some Blood Parameters at Experimental Diabetic RatsBekir Mehtap0Zafer Durgun1SELÇUK ÜNİVERSİTESİ, SPOR BİLİMLERİ FAKÜLTESİ, ANTRENÖRLÜK EĞİTİMİ BÖLÜMÜSELCUK UNIVERSITYThe aim of this study is to determine the effects of exercise on antioxidant system (MDA, SOD, GSH) and some blood parameteres (plasma insuline, glucose, ALT, AST) in rats with experimental diabetes induced by streptozotocin (STZ). In the study, 32 adult Wistar Albino rats were divided into 4 equal groups as control (C), exercise (E), diabetes (D) and diabetes+exercise (DE). Diabetes was induced in D and DE by intraperitoneal injection with a single dose of 60 mg/kg STZ. After the diabetes was induced, swimming exercise was applied to E and DE for 5 days / 30 min a week for 4 weeks. According to the findings obtained; there was a significant decrease in D and DE compared to C. Plasma glucose levels decreased in DE with exercise in the diabetic groups. While ALT levels increased significantly in diabetic groups compared to others, it was found that exercise did not make a difference in diabetics. However, the increase in AST levels was statistically significant only in D. When serum MDA levels were examined, a significant decrease was observed in DE compared to D. While there was a significant decrease in serum SOD levels in the diabetic groups compared to C. The diabetic groups and DE and E were similar to each other. A significant decrease was observed in GSH levels in D. This difference was also detected between diabetic groups. As a result; in the study it was concluded that regular aerobic exercise improved glycemic control, has a lipid peroxidation-reducing effect and may hava a positive effect on strengthening the antioxidant system in diabetes.https://dergipark.org.tr/tr/download/article-file/1728824antioxidantsexercisediabetesmellitusbloodparameters |
| spellingShingle | Bekir Mehtap Zafer Durgun The Effects of Exercise on Antioxidant System and Some Blood Parameters at Experimental Diabetic Rats Türk Spor ve Egzersiz Dergisi antioxidants exercise diabetesmellitus bloodparameters |
| title | The Effects of Exercise on Antioxidant System and Some Blood Parameters at Experimental Diabetic Rats |
| title_full | The Effects of Exercise on Antioxidant System and Some Blood Parameters at Experimental Diabetic Rats |
| title_fullStr | The Effects of Exercise on Antioxidant System and Some Blood Parameters at Experimental Diabetic Rats |
| title_full_unstemmed | The Effects of Exercise on Antioxidant System and Some Blood Parameters at Experimental Diabetic Rats |
| title_short | The Effects of Exercise on Antioxidant System and Some Blood Parameters at Experimental Diabetic Rats |
| title_sort | effects of exercise on antioxidant system and some blood parameters at experimental diabetic rats |
| topic | antioxidants exercise diabetesmellitus bloodparameters |
| url | https://dergipark.org.tr/tr/download/article-file/1728824 |
| work_keys_str_mv | AT bekirmehtap theeffectsofexerciseonantioxidantsystemandsomebloodparametersatexperimentaldiabeticrats AT zaferdurgun theeffectsofexerciseonantioxidantsystemandsomebloodparametersatexperimentaldiabeticrats AT bekirmehtap effectsofexerciseonantioxidantsystemandsomebloodparametersatexperimentaldiabeticrats AT zaferdurgun effectsofexerciseonantioxidantsystemandsomebloodparametersatexperimentaldiabeticrats |