Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice
Abstract The transsulfuration (TSS) pathway is an alternative source of cysteine for glutathione synthesis. Little of the TSS pathway in antioxidant capacity in sickle cell disease (SCD) is known. Here, we evaluate the effects of TSS pathway activation through cystathionine beta-synthase (CBS) to at...
Saved in:
Main Authors: | Caixia Xi, Junfeng Pang, Weinan Xue, Yang Cui, Na Jiang, Wenbo Zhi, Huidong Shi, Anatolij Horuzsko, Betty S. Pace, Xingguo Zhu |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-01-01
|
Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-024-07424-7 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Impact of Varicocele on The Expression of Testicular Enzymes Involved in The Transsulfuration Pathway
by: Azam Shiasi, et al.
Published: (2025-01-01) -
Sickle Cell Disease: Genetics, Cellular and Molecular Mechanisms, and Therapies
by: Betty S. Pace, et al.
Published: (2012-01-01) -
Recovery and Biodistribution of Ex Vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2Rγnull mice
by: Barbara Ghinassi, et al.
Published: (2011-01-01) -
Dual Functions of the C5a Receptor as a Connector for the K562 Erythroblast-Like Cell-THP-1 Macrophage-Like Cell Island and as a Sensor for the Differentiation of the K562 Erythroblast-Like Cell during Haemin-Induced Erythropoiesis
by: Hiroshi Nishiura, et al.
Published: (2012-01-01) -
Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis
by: Dongxu Lin, et al.
Published: (2022-01-01)