Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic
Introduction: Lyme borreliosis (LB), an infection caused by Borrelia burgdorferi sensu lato (Bbsl), is the most common tick-borne disease in Europe. To further characterize the LB burden in the Czech Republic, we conducted a seroprevalence study and estimated the incidence of symptomatic Bbsl infect...
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Elsevier
2025-03-01
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| Series: | International Journal of Medical Microbiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1438422124000481 |
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| author | Roman Chlibek Jan Smetana Kateřina Kybicová Martina Malikova Frederick J. Angulo Alexandra Loew-Baselli Ye Tan Aleš Ondřejíček Gordon Brestrich Andreas Pilz Jennifer C. Moïsi James H. Stark |
| author_facet | Roman Chlibek Jan Smetana Kateřina Kybicová Martina Malikova Frederick J. Angulo Alexandra Loew-Baselli Ye Tan Aleš Ondřejíček Gordon Brestrich Andreas Pilz Jennifer C. Moïsi James H. Stark |
| author_sort | Roman Chlibek |
| collection | DOAJ |
| description | Introduction: Lyme borreliosis (LB), an infection caused by Borrelia burgdorferi sensu lato (Bbsl), is the most common tick-borne disease in Europe. To further characterize the LB burden in the Czech Republic, we conducted a seroprevalence study and estimated the incidence of symptomatic Bbsl infections. Methods: Anti-Bbsl IgM and IgG antibodies were detected in sera collected from the adult population in 2011 −2012 by enzyme-linked immunosorbent assay and immunoblot tests at the National Reference Laboratory. The incidence of symptomatic Bbsl infections was estimated from the seroprevalence results and the symptomatic proportion and duration of persistence of anti-Bbsl IgG antibodies in Bbsl-infected individuals. Surveillance under-detection of symptomatic Bbsl infections was estimated by comparing surveillance-reported and seroprevalence-based incidence. Results: Samples from 1996 adults were tested; the median age (range) was 45 (18 −87) years; 1037 (52.0 %) were female. The prevalence (with 95 % confidence interval) of anti-Bbsl IgG, and IgM and/or IgG (IgM/IgG) antibodies was 6.3 % (5.3 −7.5 %), and 9.5 % (8.3 −10.9 %), respectively. The IgM/IgG prevalence was 7.8 % (6.5 −9.2 %) in Bohemia and 15.3 % (12.2 −19.0 %) in Moravia. There were an estimated 30,563 (26,550 −34,962) symptomatic incident Bbsl infections in adults in the Czech Republic in 2012, for an incidence of 352.2 (306.0 −402.9) symptomatic Bbsl infections per 100,000 adults per year. There were an estimated 11 (10 −13) symptomatic Bbsl infections for each surveillance-reported LB case in the Czech Republic in 2012. Conclusions: There is high incidence of symptomatic Bbsl infections in the Czech Republic, particularly in Moravia. Interventions are needed to address the substantial burden of LB in the Czech Republic. |
| format | Article |
| id | doaj-art-ca8a32e000244f17a6eb59f9edff5a8b |
| institution | Kabale University |
| issn | 1438-4221 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | International Journal of Medical Microbiology |
| spelling | doaj-art-ca8a32e000244f17a6eb59f9edff5a8b2025-01-08T04:52:19ZengElsevierInternational Journal of Medical Microbiology1438-42212025-03-01318151644Prevalence of Borrelia burgdorferi sensu lato infection in the Czech RepublicRoman Chlibek0Jan Smetana1Kateřina Kybicová2Martina Malikova3Frederick J. Angulo4Alexandra Loew-Baselli5Ye Tan6Aleš Ondřejíček7Gordon Brestrich8Andreas Pilz9Jennifer C. Moïsi10James H. Stark11Military Medical Faculty, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech RepublicMilitary Medical Faculty, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech RepublicNational Reference Laboratory for Lyme Borreliosis, National Health Institute, Šrobárova 49/48, Prague 10, 100 00, Czech RepublicMilitary Medical Faculty, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech RepublicGlobal Vaccines and Anti-infectives Medical Affairs, Pfizer Inc., Collegeville, 500 Arcola Road, PA 19426, USA; Corresponding author.Global Vaccines and Anti-infectives Medical Affairs, Pfizer Corporation Austria, Floridsdorfer Hauptstraße 1, Vienna 1210, AustriaEvidence Generation Statistics, Pfizer Inc., 1 Portland Street, Cambridge, MA 02139, USAPfizer spol. s r.o., Stroupežnického 3191/17, Praha 5, 150 00, Czech RepublicGlobal Vaccines and Anti-infectives Medical Affairs, Pfizer Pharma GmbH, Friedrichstraße, Berlin 110-10117, GermanyGlobal Vaccines and Anti-infectives Medical Affairs, Pfizer Corporation Austria, Floridsdorfer Hauptstraße 1, Vienna 1210, AustriaGlobal Vaccines and Anti-infectives Medical Affairs, 23 Avenue du Docteur Lannelongue, Paris 75014, FranceGlobal Vaccines, and Anti-infectives Medical Affairs, Pfizer Inc., 1 Portland Street, Cambridge, MA 02139, USAIntroduction: Lyme borreliosis (LB), an infection caused by Borrelia burgdorferi sensu lato (Bbsl), is the most common tick-borne disease in Europe. To further characterize the LB burden in the Czech Republic, we conducted a seroprevalence study and estimated the incidence of symptomatic Bbsl infections. Methods: Anti-Bbsl IgM and IgG antibodies were detected in sera collected from the adult population in 2011 −2012 by enzyme-linked immunosorbent assay and immunoblot tests at the National Reference Laboratory. The incidence of symptomatic Bbsl infections was estimated from the seroprevalence results and the symptomatic proportion and duration of persistence of anti-Bbsl IgG antibodies in Bbsl-infected individuals. Surveillance under-detection of symptomatic Bbsl infections was estimated by comparing surveillance-reported and seroprevalence-based incidence. Results: Samples from 1996 adults were tested; the median age (range) was 45 (18 −87) years; 1037 (52.0 %) were female. The prevalence (with 95 % confidence interval) of anti-Bbsl IgG, and IgM and/or IgG (IgM/IgG) antibodies was 6.3 % (5.3 −7.5 %), and 9.5 % (8.3 −10.9 %), respectively. The IgM/IgG prevalence was 7.8 % (6.5 −9.2 %) in Bohemia and 15.3 % (12.2 −19.0 %) in Moravia. There were an estimated 30,563 (26,550 −34,962) symptomatic incident Bbsl infections in adults in the Czech Republic in 2012, for an incidence of 352.2 (306.0 −402.9) symptomatic Bbsl infections per 100,000 adults per year. There were an estimated 11 (10 −13) symptomatic Bbsl infections for each surveillance-reported LB case in the Czech Republic in 2012. Conclusions: There is high incidence of symptomatic Bbsl infections in the Czech Republic, particularly in Moravia. Interventions are needed to address the substantial burden of LB in the Czech Republic.http://www.sciencedirect.com/science/article/pii/S1438422124000481Lyme borreliosisLyme diseaseepidemiologydisease burdenseroprevalencesurveillance |
| spellingShingle | Roman Chlibek Jan Smetana Kateřina Kybicová Martina Malikova Frederick J. Angulo Alexandra Loew-Baselli Ye Tan Aleš Ondřejíček Gordon Brestrich Andreas Pilz Jennifer C. Moïsi James H. Stark Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic International Journal of Medical Microbiology Lyme borreliosis Lyme disease epidemiology disease burden seroprevalence surveillance |
| title | Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic |
| title_full | Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic |
| title_fullStr | Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic |
| title_full_unstemmed | Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic |
| title_short | Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic |
| title_sort | prevalence of borrelia burgdorferi sensu lato infection in the czech republic |
| topic | Lyme borreliosis Lyme disease epidemiology disease burden seroprevalence surveillance |
| url | http://www.sciencedirect.com/science/article/pii/S1438422124000481 |
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