The therapeutic potential of apigenin against atherosclerosis
Apigenin is a natural flavonoid abundantly found in fruits, vegetables, and medicinal plants. It possesses protective effects against cancer, metabolic syndrome, dyslipidemia, etc. Atherosclerosis, a chronic immune-mediated inflammatory disease, is the underlying cause of coronary heart disease, str...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024173033 |
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| _version_ | 1841526227885621248 |
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| author | Xueqiang Jiang Huimin Huang |
| author_facet | Xueqiang Jiang Huimin Huang |
| author_sort | Xueqiang Jiang |
| collection | DOAJ |
| description | Apigenin is a natural flavonoid abundantly found in fruits, vegetables, and medicinal plants. It possesses protective effects against cancer, metabolic syndrome, dyslipidemia, etc. Atherosclerosis, a chronic immune-mediated inflammatory disease, is the underlying cause of coronary heart disease, stroke, and myocardial infarction. Numerous in vivo and in vitro studies have shown a protective effect of apigenin against atherosclerosis, attributed to its antioxidant and anti-inflammatory properties, as well as its antihypertensive effect and regulation of lipid metabolism. This study aimed to review the effects and mechanisms of apigenin against atherosclerosis for the first time. Apigenin displays encouraging results, and this review confirms the potential value of apigenin as a candidate medication for atherosclerosis. |
| format | Article |
| id | doaj-art-ca6e69a0e32d4399827c1bffd6c99b86 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-ca6e69a0e32d4399827c1bffd6c99b862025-01-17T04:50:43ZengElsevierHeliyon2405-84402025-01-01111e41272The therapeutic potential of apigenin against atherosclerosisXueqiang Jiang0Huimin Huang1Sinopharm Dongfeng General Hospital, Hubei Clinical Research Center of Hypertension, Hubei University of Medicine, Shiyan, 442008, ChinaSinopharm Dongfeng General Hospital, Hubei Clinical Research Center of Hypertension, Hubei University of Medicine, Shiyan, 442008, China; Department of Pharmacy, Xi'an Jiaotong University, Xi'an, 710003, China; Corresponding author. Sinopharm Dongfeng General Hospital, Hubei Clinical Research Center of Hypertension, Hubei University of Medicine, Shiyan, 442008, China.Apigenin is a natural flavonoid abundantly found in fruits, vegetables, and medicinal plants. It possesses protective effects against cancer, metabolic syndrome, dyslipidemia, etc. Atherosclerosis, a chronic immune-mediated inflammatory disease, is the underlying cause of coronary heart disease, stroke, and myocardial infarction. Numerous in vivo and in vitro studies have shown a protective effect of apigenin against atherosclerosis, attributed to its antioxidant and anti-inflammatory properties, as well as its antihypertensive effect and regulation of lipid metabolism. This study aimed to review the effects and mechanisms of apigenin against atherosclerosis for the first time. Apigenin displays encouraging results, and this review confirms the potential value of apigenin as a candidate medication for atherosclerosis.http://www.sciencedirect.com/science/article/pii/S2405844024173033ApigeninAtherosclerosisAntioxidantAnti-inflammatoryLipid metabolism |
| spellingShingle | Xueqiang Jiang Huimin Huang The therapeutic potential of apigenin against atherosclerosis Heliyon Apigenin Atherosclerosis Antioxidant Anti-inflammatory Lipid metabolism |
| title | The therapeutic potential of apigenin against atherosclerosis |
| title_full | The therapeutic potential of apigenin against atherosclerosis |
| title_fullStr | The therapeutic potential of apigenin against atherosclerosis |
| title_full_unstemmed | The therapeutic potential of apigenin against atherosclerosis |
| title_short | The therapeutic potential of apigenin against atherosclerosis |
| title_sort | therapeutic potential of apigenin against atherosclerosis |
| topic | Apigenin Atherosclerosis Antioxidant Anti-inflammatory Lipid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024173033 |
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