Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart

Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart

Abstract Inflammation and a metabolic shift from oxidative metabolism to glycolysis are common in the ischemic heart, the latter partly controlled by pyruvate kinase (muscle, PKM). We previously identified alternative splicing promoting the PKM2 isoform after myocardial infarction (MI). We examined...

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Bibliographic Details
Main Authors: Katie C. Y. Lee, Allison L. Williams, Akitoshi Hara, Vedbar S. Khadka, Jeffrey Hayashi, Ralph V. Shohet
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Physiological Reports
Subjects:
fibrosis
inflammation
myocardial infarction
oxidative stress
Online Access:https://doi.org/10.14814/phy2.70193
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