Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses
Objectives To conduct an umbrella review to extensively evaluate and summarise the evidence regarding the relationship between risk factors and the occurrence of brain metastasis in lung cancer.Design Umbrella review of systematic reviews and meta-analyses.Data sources Four databases (PubMed, EMBASE...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/1/e087181.full |
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| author | Sumei Wang Xinliang Wan Handan Mo Jixin Chen Qichun Zhou Shenghong Qiu Yongchun Zou Wanyin Wu Qing Tang |
| author_facet | Sumei Wang Xinliang Wan Handan Mo Jixin Chen Qichun Zhou Shenghong Qiu Yongchun Zou Wanyin Wu Qing Tang |
| author_sort | Sumei Wang |
| collection | DOAJ |
| description | Objectives To conduct an umbrella review to extensively evaluate and summarise the evidence regarding the relationship between risk factors and the occurrence of brain metastasis in lung cancer.Design Umbrella review of systematic reviews and meta-analyses.Data sources Four databases (PubMed, EMBASE, Web of Science and Cochrane Library) were searched from inception to 10 November 2024.Eligibility criteria Systematic reviews and meta-analyses that assessed the relationship between risk factors and brain metastasis in lung cancer were included. Only English language studies were considered.Data extraction and synthesis Two authors independently extracted data and assessed the methodological quality and risk of bias of the included studies. Certainty of evidence was evaluated and summarised for each identified risk factor.Results Six systematic reviews/meta-analyses were included. The quality of these studies varied, with most having low or critically low methodological quality. Epidermal growth factor receptor mutations, female gender, lung adenocarcinoma and advanced tumour stage were associated with an increased risk of brain metastasis. Prophylactic cranial irradiation and older age were associated with reduced risk.Conclusions This umbrella review suggests that several risk factors may be associated with brain metastasis in lung cancer, but the overall quality of evidence is low. Future studies with improved methodologies are needed to validate these findings.PROSPERO registration number CRD42023484563 |
| format | Article |
| id | doaj-art-ca531d1578084d388b8fe089d700d75a |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-ca531d1578084d388b8fe089d700d75a2025-01-09T14:50:09ZengBMJ Publishing GroupBMJ Open2044-60552025-01-0115110.1136/bmjopen-2024-087181Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analysesSumei Wang0Xinliang Wan1Handan Mo2Jixin Chen3Qichun Zhou4Shenghong Qiu5Yongchun Zou6Wanyin Wu7Qing Tang82 Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLC, Department of Oncology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Chinese Medicine Guangdong Laboratory, Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China1 The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China1 The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China1 The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China2 Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLC, Department of Oncology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Chinese Medicine Guangdong Laboratory, Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China3 Department of Radiotherapy, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China1 The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China2 Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLC, Department of Oncology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Chinese Medicine Guangdong Laboratory, Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China2 Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLC, Department of Oncology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Chinese Medicine Guangdong Laboratory, Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaObjectives To conduct an umbrella review to extensively evaluate and summarise the evidence regarding the relationship between risk factors and the occurrence of brain metastasis in lung cancer.Design Umbrella review of systematic reviews and meta-analyses.Data sources Four databases (PubMed, EMBASE, Web of Science and Cochrane Library) were searched from inception to 10 November 2024.Eligibility criteria Systematic reviews and meta-analyses that assessed the relationship between risk factors and brain metastasis in lung cancer were included. Only English language studies were considered.Data extraction and synthesis Two authors independently extracted data and assessed the methodological quality and risk of bias of the included studies. Certainty of evidence was evaluated and summarised for each identified risk factor.Results Six systematic reviews/meta-analyses were included. The quality of these studies varied, with most having low or critically low methodological quality. Epidermal growth factor receptor mutations, female gender, lung adenocarcinoma and advanced tumour stage were associated with an increased risk of brain metastasis. Prophylactic cranial irradiation and older age were associated with reduced risk.Conclusions This umbrella review suggests that several risk factors may be associated with brain metastasis in lung cancer, but the overall quality of evidence is low. Future studies with improved methodologies are needed to validate these findings.PROSPERO registration number CRD42023484563https://bmjopen.bmj.com/content/15/1/e087181.full |
| spellingShingle | Sumei Wang Xinliang Wan Handan Mo Jixin Chen Qichun Zhou Shenghong Qiu Yongchun Zou Wanyin Wu Qing Tang Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses BMJ Open |
| title | Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses |
| title_full | Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses |
| title_fullStr | Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses |
| title_full_unstemmed | Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses |
| title_short | Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses |
| title_sort | risk factors for brain metastasis in lung cancer an umbrella review of systematic reviews and meta analyses |
| url | https://bmjopen.bmj.com/content/15/1/e087181.full |
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