Liquiritin improves macrophage degradation of engulfed tumour cells by promoting the formation of phagolysosomes via NOX2/gp91phox

Liquiritin improves macrophage degradation of engulfed tumour cells by promoting the formation of phagolysosomes via NOX2/gp91phox

The incomplete degradation of tumour cells by macrophages (Mϕ) is a contributing factor to tumour progression and metastasis, and the degradation function of Mϕ is mediated through phagosomes and lysosomes. In our preliminary experiments, we found that overactivation of NADPH oxidase 2 (NOX2) reduce...

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Bibliographic Details
Main Authors: Caiyi Yang, Kehan Chen, Yunliang Chen, Xuting Xie, Pengcheng Li, Meng Zhao, Junjie Liang, Xueqian Xie, Xiaoyun Chen, Yanping Cai, Bo Xu, Qing Wang, Lian Zhou, Xia Luo
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Liquiritin
Macrophages
NADPH oxidase 2
Reactive oxygen species
Phagocytosis
Neoplasms
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177924001904
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