Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study
Background and Aims: Chronic pancreatitis (CP) is a disease that is present in multiple different geographic populations and is treated similarly around the world. No study has directly compared geographic differences in clinical characteristics of CP populations from Western and other regions, nor...
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Elsevier
2025-01-01
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| Series: | Gastro Hep Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572325001074 |
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| author | Misbah Unnisa Mahya Faghih Asbjørn Mohr Drewes Vikesh K. Singh Dhiraj Yadav Rupjyoti Talukdar Søren Schou Olesen Anna Evans Phillips |
| author_facet | Misbah Unnisa Mahya Faghih Asbjørn Mohr Drewes Vikesh K. Singh Dhiraj Yadav Rupjyoti Talukdar Søren Schou Olesen Anna Evans Phillips |
| author_sort | Misbah Unnisa |
| collection | DOAJ |
| description | Background and Aims: Chronic pancreatitis (CP) is a disease that is present in multiple different geographic populations and is treated similarly around the world. No study has directly compared geographic differences in clinical characteristics of CP populations from Western and other regions, nor quality of life experiences. Methods: This cross-sectional, multicenter study of adults (≥18 years) with definite CP recruited subjects at 4 centers from the Pancreatic Pain Consortium. Demographics, clinical and disease characteristics, and patient-reported outcomes, including Hospital Anxiety and Depression Scale and European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores were obtained. Due to similarities in population characteristics, European and United States subjects were grouped together into a Western population. Results: A total of 528 subjects were included (Indian n = 254, Western n = 274). Compared to the Indian cohort, the Western cohort had higher mean age at enrollment (54.5 ± 13.5 v 35.9 ± 11.8 years), older age distribution, higher rates of current alcohol use (34% v 2%) and alcohol etiology of CP (53% v 17%), more constant pain (50% v 20%), higher prevalence of exocrine pancreatic insufficiency (66% v 44%), and higher rates of endoscopic treatment (61% v 43%) (all P < .001). The Western cohort also reported lower global health and worse scores in physical, role, cognitive, and social functioning with a reduction in overall global health in multivariable regression analyses (−7.2 points [95% confidence interval −13.5 to −1.0] P = .023). Conclusion: There appear to be demographic, etiological, and quality of life differences in the experience of CP across different populations. Reasons for these differences, including potential cultural and societal forces, need to be further explored. |
| format | Article |
| id | doaj-art-c9cc86dfa7d24d38b83187b0fc515f06 |
| institution | Kabale University |
| issn | 2772-5723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj-art-c9cc86dfa7d24d38b83187b0fc515f062025-08-24T05:15:30ZengElsevierGastro Hep Advances2772-57232025-01-014910072010.1016/j.gastha.2025.100720Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter StudyMisbah Unnisa0Mahya Faghih1Asbjørn Mohr Drewes2Vikesh K. Singh3Dhiraj Yadav4Rupjyoti Talukdar5Søren Schou Olesen6Anna Evans Phillips7Pancreas Research Group, Asian Institute of Gastroenterology, Hyderabad, IndiaDivision of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland; Pancreatitis Center, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MarylandDepartment of Gastroenterology and Hepatology, Centre for Pancreatic Diseases and Mech-Sense, Manipal, India; Department of Clinical Medicine, Aalborg University, Aalborg, DenmarkDivision of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland; Pancreatitis Center, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MarylandDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PennsylvaniaPancreas Research Group, Asian Institute of Gastroenterology, Hyderabad, IndiaDepartment of Gastroenterology and Hepatology, Centre for Pancreatic Diseases and Mech-Sense, Manipal, India; Department of Clinical Medicine, Aalborg University, Aalborg, DenmarkDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Correspondence: Address correspondence to: Anna Evans Phillips MD, MS, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, Mezzanine Level M-2, Pittsburgh, Pennsylvania 15213.Background and Aims: Chronic pancreatitis (CP) is a disease that is present in multiple different geographic populations and is treated similarly around the world. No study has directly compared geographic differences in clinical characteristics of CP populations from Western and other regions, nor quality of life experiences. Methods: This cross-sectional, multicenter study of adults (≥18 years) with definite CP recruited subjects at 4 centers from the Pancreatic Pain Consortium. Demographics, clinical and disease characteristics, and patient-reported outcomes, including Hospital Anxiety and Depression Scale and European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores were obtained. Due to similarities in population characteristics, European and United States subjects were grouped together into a Western population. Results: A total of 528 subjects were included (Indian n = 254, Western n = 274). Compared to the Indian cohort, the Western cohort had higher mean age at enrollment (54.5 ± 13.5 v 35.9 ± 11.8 years), older age distribution, higher rates of current alcohol use (34% v 2%) and alcohol etiology of CP (53% v 17%), more constant pain (50% v 20%), higher prevalence of exocrine pancreatic insufficiency (66% v 44%), and higher rates of endoscopic treatment (61% v 43%) (all P < .001). The Western cohort also reported lower global health and worse scores in physical, role, cognitive, and social functioning with a reduction in overall global health in multivariable regression analyses (−7.2 points [95% confidence interval −13.5 to −1.0] P = .023). Conclusion: There appear to be demographic, etiological, and quality of life differences in the experience of CP across different populations. Reasons for these differences, including potential cultural and societal forces, need to be further explored.http://www.sciencedirect.com/science/article/pii/S2772572325001074chronic pancreatitisgeographic differenceslife qualityquality of life |
| spellingShingle | Misbah Unnisa Mahya Faghih Asbjørn Mohr Drewes Vikesh K. Singh Dhiraj Yadav Rupjyoti Talukdar Søren Schou Olesen Anna Evans Phillips Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study Gastro Hep Advances chronic pancreatitis geographic differences life quality quality of life |
| title | Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study |
| title_full | Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study |
| title_fullStr | Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study |
| title_full_unstemmed | Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study |
| title_short | Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study |
| title_sort | geographic differences in the quality of life associated with chronic pancreatitis an international multicenter study |
| topic | chronic pancreatitis geographic differences life quality quality of life |
| url | http://www.sciencedirect.com/science/article/pii/S2772572325001074 |
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